GASTRIN PATHOPHYSIOLOGY - ANTISECRETORY DRUGS

被引：0

作者：

DELLEFAVE, G ^{[1
]}

ANNIBALE, B ^{[1
]}

DEMAGISTRIS, L ^{[1
]}

机构：

[1] UNIV ROME LA SAPIENZA,CATTEDRA GASTROENTEROL 1,I-00185 ROME,ITALY

来源：

ITALIAN JOURNAL OF GASTROENTEROLOGY | 1990年 / 22卷

关键词：

GASTRIN; GASTRIC ACID SECRETION; ANTISECRETORY DRUGS;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The management of maintenance therapy in peptic disease (oesophagus, stomach, duodenum) with antisecretory drugs should keep in consideration the aspect of developing hypergastrinemia: gastrin exerts a throphic effect on gastric ECL and parietal cells. After a long term maintenance therapy (3-5) years) with ranitidine 150mg/die in a group of 55 patients affected by duodenal ulcer, 20% of them developed hypergastrinemia and gastric hypersecretion (evaluated after one week of drug withdrawal). The same 20% of the subjects showed increased relapse rates with respect to those who did develop the same gastrin/gastric acid increase.

引用

页码：32 / 35

页数：4

共 50 条

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