STRATEGIES FOR MAPPING AND IMITATING VIRAL B-CELL EPITOPES

被引：13
|
作者：
CASON, J
机构：
[1] The Richard Dimbleby Laboratory for Cancer Virology, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, Lambeth Palace Road
来源：
JOURNAL OF VIROLOGICAL METHODS | 1994年 / 49卷 / 02期
关键词：
VIRUS; EPITOPE MAPPING; ANTIBODY;
D O I：
10.1016/0166-0934(94)90045-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.
引用
收藏
页码：209 / 219
页数：11
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