Huntington's disease

Huntington disease is an autosomal dominantly transmitted disorder. Huntingtin is the abnormal protein produced by the repeat of the CAG triplet. It is characterized by motor abnormalities, cognitive dysfunction and dementia. It has comorbidity with psychiatric manifestations like depression, present in half of the patients. Psychosis, irritability, apathy, obsessive symptoms and delirium may be present too. There is no cure for the disease. Interventions are aimed to treat symptoms like motor abnormalities and psychiatric manifestations.