EFFICACY OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE TREATMENT AGAINST CHRONIC SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN MACAQUES

被引：32

作者：

TSAI, CC

FOLLIS, KE

SABO, A

GRANT, R

BISCHOFBERGER, N

机构：

[1] UNIV WASHINGTON,REG PRIMATE RES CTR,SEATTLE,WA 98195

[2] GILEAD SCI,FOSTER CITY,CA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 05期

关键词：

D O I：

10.1093/infdis/171.5.1338

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long-tailed macaques chronically infected with simian immunodeficiency virus (SIV) were treated for 4 or 8 weeks with daily subcutaneous doses of the antiretroviral compound 9-(2-phosphonylmethoxyethyl)adenine (PMEA). The efficacy of PMEA was evaluated by monitoring cell-free virus in plasma, virus titer and viral DNA in peripheral blood mononuclear cells, and absolute numbers of lymphocyte subsets. In mock-treated control macaques, virus titers changed minimally. However, in treated macaques, PMEA exhibited impressive effects, leading to the disappearance of virus in the blood within the first week of treatment and lasting through the fourth week of treatment. The results indicate that PMEA can effectively reduce SIV in chronically infected macaques and offer an optimistic perspective for therapeutic intervention against human immunodeficiency virus infection.

引用

页码：1338 / 1343

页数：6

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