PREPARATION OF 1,2-DIMETHOXY-4-(BIS-DIETHYLAMINOETHYL-[C-14]-AMINO)-5-BROMOBENZENE

被引：0

作者：

WANG, TST ^{[1
]}

FAWWAZ, RA ^{[1
]}

VANHEERTUM, RH ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT RADIOL,DIV NUCL MED,NEW YORK,NY 10032

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 11期

关键词：

ANTIMALARIAL AGENT; RC-12-[C-14; CHLORINATION; GRIGNARD REAGENT; BIS-N-ALKYLATION;

D O I：

10.1002/jlcr.2580331103

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

1,2-Dimethoxy-4-(bis-diethylaminoethyl-[C-14] -amino)-5-bromobenzene (III) was synthesized for in vivo pharmacokinetic and pharmacodynamic evaluation. The synthesis of (III) was easily obtained by the direct alkylation of 1,2-dimethoxy-5-bromo-aniline with beta-diethylaminoethyl chloride-ethylene-[C-14], using CH3MgCl as the proton abstractor. Compound III was obtained with a 22.3% yield. The specific activity was 2.2mCi/mmol, with a radiochemical purity of >99%.

引用

页码：1007 / 1012

页数：6

共 50 条

[41] PREPARATION OF 1-METHYL-4-[4-(7-CHLORO-4-QUINOLYL-[3-C-14]-AMINO)BENZOYL]PIPERAZINE
WANG, TST
FAWWAZ, RA
VANHEERTUM, RL
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1995, 36 (04): : 313 - 320
[42] Heterocyclization and functionalization of 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene
Reda A. Haggam
Research on Chemical Intermediates, 2015, 41 : 1135 - 1148
[43] Heterocyclization and functionalization of 1,2-bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene
Haggam, Reda A.
RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (02) : 1135 - 1148
[44] Preparation of [C-14]-labelled 1,2,3,4,6-penta-O-galloyl-beta-D-glucose and related gallotannins
Rausch, H
Gross, GG
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 1996, 51 (7-8): : 473 - 476
[45] Crystal structure of 1,1′-(1,2-ethanediyl)bis(pyridin-1-ium) bis(1,2-dicyanoethene-1,2-dithiolato-κ2 S:S)zinc(II), C20H14N6ZnS4
Liu, Xue-Guo
Chen, Wan-Yao
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2022, 237 (05): : 837 - 839
[46] SYNTHESIS OF [1,2-CYCLOHEXANEDIONE-1-C-14 BIS(4-DIETHYLENOXYTHIOSEMICARBAZONE) AND PRELIMINARY BIODISTRIBUTION STUDIES OF THIS POTENTIAL ANTI-TUMOR AGENT
MORGAN, HK
VARUGHESE, A
WILLIAMS, L
INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1983, 34 (11): : 1501 - 1504
[47] THE METABOLIC DEGRADATION OF 1,2,5,6-DIBENZANTHRACENE-9,10- C-14 .2. 5-HYDROXY-1,2-NAPHTHALIC ANHYDRIDE, A NEW METABOLITE
HEIDELBERGER, C
WIEST, WG
CANCER RESEARCH, 1950, 10 (04) : 223 - 224
[48] Crystal structure of 1,1′-(1,2-ethanediyl)bis(pyridin-1-ium) bis(1,2-dicyanoethene-1,2-dithiolato-κ2S:S)nickel(II), C20H14N6NiS4
Yan, Wei-Hong
Chen, Wan-Yao
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2022, 237 (02): : 235 - 236
[49] [4+2] CYCLO-ADDITION REACTION OF BIS (TRICHLOROETHYL) AZODICARBOXYLATE AND GLYCALS - PREPARATION OF A C1-C1 2-AMINO DISACCHARIDE
LEBLANC, Y
FITZSIMMONS, BJ
TETRAHEDRON LETTERS, 1989, 30 (22) : 2889 - 2892
[50] SYNTHESES DU DIBROMO-1,5 PENTANE (C-14-1), DU RHO-HYDROXYBENZONITRILE (CYANO C-14) ET LEUR EMPLOI POUR LA PREPARATION, DE BIS-(P-AMIDINO PHENOXY)-1,5 PENTANE (LOMIDINE, PENTAMIDINE, 2512 RP) RADIOACTIF
PICHAT, L
BARET, C
AUDINOT, M
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1956, (01): : 151 - 156

← 1 2 3 4 5 →