OKADAIC ACID STIMULATES CARNITINE PALMITOYLTRANSFERASE-I ACTIVITY AND PALMITATE OXIDATION IN ISOLATED RAT HEPATOCYTES

被引：21
|
作者：
GUZMAN, M [1 ]
CASTRO, J [1 ]
机构：
[1] COMPLUTENSE UNIV MADRID,FAC CHEM,DEPT BIOCHEM & MOLEC BIOL 1,E-28040 MADRID,SPAIN
来源：
FEBS LETTERS | 1991年 / 291卷 / 01期
关键词：
OKADAIC ACID; FATTY ACID OXIDATION; CARNITINE PALMITOYLTRANSFERASE-I; HEPATOCYTE;
D O I：
10.1016/0014-5793(91)81114-N
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Okadaic acid increased in parallel with carnitine palmitoyltransferase I activity and the rate of palmitate oxidation in isolated rat hepatocytes. Nevertheless, okadaic acid had no significant effect on the rate of octanoate oxidation. Maximal effects of okadaic acid were similar and non-additive to those of dibutyryl-cAMP, forskolin and glucagon. Results indicate that carnitine palmitoyltransferase I activity may be controlled by a mechanism of phosphorylation/dephosphorylation.
引用
收藏
页码：105 / 108
页数：4
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