STATIC AND SCANNING ARRAY DETECTION IN CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY

被引：25
|
作者：
REINHOUD, NJ
SCHRODER, E
TJADEN, UR
NIESSEN, WMA
DEBRAUW, MCT
VANDERGREEF, J
机构：
[1] CTR BIOPHARMACEUT SCI, DIV ANALYT CHEM, POB 9502, 2300 RA LEIDEN, NETHERLANDS
[2] FINNIGAN MAT GMBH, W-2800 BREMEN 14, GERMANY
[3] TNO, CIVO INST, INSTRUMENTAL ANAL SECT, 3700 AJ ZEIST, NETHERLANDS
来源：
JOURNAL OF CHROMATOGRAPHY | 1990年 / 516卷 / 01期
关键词：
D O I：
10.1016/S0021-9673(01)90212-2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An array detection system based on position- and time-resolved ion counting was evaluated for capillary electrophoresis-mass spectrometry using continuous-flow fast atom bombardment and a liquid-junction coupling. Peptides with molecular masses up to 3200 were measured. A 100-1000-fold improvement over conventional detection was demonstrated by applying the array detector in scanning and static modes. Absolute detection limits in the range 1-5 fmol are achievable. © 1990.
引用
收藏
页码：147 / 155
页数：9
相关论文
共 50 条
  • [1] CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY
    CAI, JY
    HENION, J
    JOURNAL OF CHROMATOGRAPHY A, 1995, 703 (1-2) : 667 - 692
  • [2] CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY
    NIESSEN, WMA
    TJADEN, UR
    VANDERGREEF, J
    JOURNAL OF CHROMATOGRAPHY, 1993, 636 (01): : 3 - 19
  • [3] Capillary electrophoresis tandem mass spectrometry with array detection
    Deterding, LJ
    Tomer, KB
    Wellemans, JMY
    Cerny, RL
    Gross, ML
    EUROPEAN MASS SPECTROMETRY, 1999, 5 (01): : 33 - 40
  • [4] REDUCED ELUTION SPEED DETECTION FOR CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY
    GOODLETT, DR
    WAHL, JH
    UDSETH, HR
    SMITH, RD
    JOURNAL OF MICROCOLUMN SEPARATIONS, 1993, 5 (01) : 57 - 62
  • [5] DETECTION OF NONCOVALENT FKBP FK506 AND FKBP RAPAMYCIN COMPLEXES BY CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY AND CAPILLARY ELECTROPHORESIS TANDEM MASS-SPECTROMETRY
    HSIEH, YL
    CAI, JY
    LI, YT
    HENION, JD
    GANEM, B
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1995, 6 (02) : 85 - 90
  • [6] CAPILLARY ELECTROPHORESIS AND CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY IN DRUG AND METABOLITE ANALYSIS
    NAYLOR, S
    TOMLINSON, AJ
    BENSON, LM
    GORROD, JW
    EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1994, 19 (03) : 235 - 240
  • [7] MASS-SPECTROMETRY OF PROTEINS ISOLATED BY CAPILLARY ELECTROPHORESIS
    TAKIGIKU, R
    KEOUGH, T
    LACEY, MP
    PURDON, M
    SCHNEIDER, RE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 145 - ANYL
  • [8] PHYSICOCHEMICAL DATA ON PEPTIDES AND PROTEINS BY CAPILLARY ELECTROPHORESIS AND CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY
    JORGENSON, JW
    MOSELEY, WA
    MOORE, AW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 201 : 55 - ANYL
  • [9] INDUSTRIAL APPLICATIONS OF CAPILLARY ZONE ELECTROPHORESIS MASS-SPECTROMETRY
    NIELEN, MWF
    JOURNAL OF CHROMATOGRAPHY A, 1995, 712 (01) : 269 - 284
  • [10] PRELIMINARY INVESTIGATIONS OF PRECONCENTRATION CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY
    TOMLINSON, AJ
    BRADDOCK, WD
    BENSON, LM
    ODA, RP
    NAYLOR, S
    JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 669 (01): : 67 - 73
12345