CYTOTOXIC HYDROXYPOLYGODIALS - X-RAY MOLECULAR-STRUCTURE OF (1R,3S,5AS,-9AS,9BR)-1,3,5,5A,6,7,8,9,9A,9B-DECAHYDRO-1,3-DIMETHOXY-6,6,9A-TRIMETHYLNAPHTHO[1,2-C]FURAN

被引：18
|
作者：
TOZYO, T [1 ]
YASUDA, F [1 ]
NAKAI, H [1 ]
TADA, H [1 ]
机构：
[1] SHIONOGI & CO LTD,SHIONOGI RES LAB,FUKUSHIMA KU,OSAKA 553,JAPAN
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 14期
关键词：
D O I：
10.1039/p19920001859
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hydroxypolygodials, designed to have the simplified structure of the cytotoxic sesterterpene deacetylscalaradial isolated from the marine sponge Cacospongia scalaris, were synthesized starting from polygodial via fungal hydroxylation and chemical modification, and the expected biological activities were obtained. All the structures of the products were determined by mainly spectroscopic means. A simple method for removal of chlorophyll was devised, resulting in considerable improvement in the yield of polygodial.
引用
收藏
页码：1859 / 1866
页数：8
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