ISOLATION OF MUTANTS BLOCKED IN CALICHEAMICIN BIOSYNTHESIS

被引：7
|
作者：
ROTHSTEIN, DM
LOVE, SF
机构：
来源：
JOURNAL OF BACTERIOLOGY | 1991年 / 173卷 / 23期
关键词：
D O I：
10.1128/jb.173.23.7716-7718.1991
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also described.
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页码：7716 / 7718
页数：3
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