SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES AND THEIR RESISTANCE TO THE ACTION OF SNAKE-VENOM PHOSPHODIESTERASE

被引：0

作者：

ORETSKAYA, TS

IBRAGIM, HKH

VOLKOV, EM

ROMANOVA, EA

TASHLITSKY, VN

SHABAROVA, ZA

机构：

来源：

BIOORGANICHESKAYA KHIMIYA | 1994年 / 20卷 / 8-9期

关键词：

1-(BETA-D-3'-DEOXY-THREO-PENTOFURANOSYL)PYRIMIDINES; MODIFIED OLIGONUCLEOTIDES; SNAKE VENOM PHOSPHODIESTERASE;

D O I：

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中图分类号：

学科分类号：

摘要：

Effective methods of multiple incorporations of nucleotides with the inverted configuration of C2' hydroxyl group have been developed. The presence of tU and tC as 3'-terminal oligonucleotide modifications is shown to increase their resistance to snake venom phosphodiesterase. The obtained compounds are promising for the use in antisense biotechnology.

引用

页码：967 / 974

页数：8

共 26 条

[21] SYNTHESIS OF 1-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-ETHYNYL-1,2,3,4-TETRAHYDROPYRIMIDINE-2,4-DIONE (5-ETHYNYL-2'-DEOXYURIDINE)
PERMAN, J
SHARMA, RA
BOBEK, M
TETRAHEDRON LETTERS, 1976, (28) : 2427 - 2430
[22] The action of diethylaminosulfur trifluoride (DAST) on 1-(4,6-O-isopropylidene-β-D-glucopyranosyl)pyrimidines, a one-pot synthesis of 2,2'-anhydro-1-(3-deoxy-3-fluoro-4,6-O-isopropylidene-β-D-altropyranos yl)pyrimidines
Leclerq, Francoise, 1600, (222):
[23] SYNTHETIC STUDIES IN CARBOHYDRATES .53. SYNTHESIS OF O-(2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL)-(1-]3)-O-BETA-D-GALACTOPYRANOSYL-(1-]4)-2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSE AND 2 RELATED TRISACCHARIDES CONTAINING THE LACTO-N-BIOSE-II UNIT
THOMAS, RL
DUBEY, R
ABBAS, SA
MATTA, KL
CARBOHYDRATE RESEARCH, 1987, 169 : 201 - 212
[24] SYNTHETIC STUDIES IN CARBOHYDRATES .63. SYNTHETIC MUCIN FRAGMENTS - SYNTHESIS OF A TETRA-SACCHARIDE AND 2 PENTA-SACCHARIDES CONTAINING THE O-BETA-D-GALACTOPYRANOSYL-(1-]3)-O-(2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL)-(1-]3)-D-GALACTOPYRANOSE (LACTO-N-TRIOSE-1) UNIT
JAIN, RK
KOHATA, K
ABBAS, SA
MATTA, KL
CARBOHYDRATE RESEARCH, 1988, 182 (02) : 290 - 296
[25] SYNTHETIC STUDIES IN CARBOHYDRATES .68. SYNTHESIS OF BENZYL O-(2-O-METHYL-BETA-D-GALACTOPYRANOSYL)-(1-]3)-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE [BENZYL 2'-O-METHYLLACTO-N-BIOSIDE I], AND ITS HIGHER SACCHARIDE CONTAINING AN O-(2-O-METHYL-BETA-D-GALACTOPYRANOSYL)-(1-]3)-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL GROUP AS A POTENTIAL SUBSTRATE FOR (1-]4)-ALPHA-L-FUCOSYL-TRANSFERASE
SARKAR, AK
JAIN, RK
MATTA, KL
CARBOHYDRATE RESEARCH, 1990, 203 (01) : 33 - 46
[26] SYNTHETIC STUDIES IN CARBOHYDRATES .79. A FACILE SYNTHESIS OF NITROPHENYL OLIGOSACCHARIDES CONTAINING THE O-ALPHA-L-FUCOPYRANOSYL-(1-]3)-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSYL UNIT AT THEIR NONREDUCING END
JAIN, RK
PISKORZ, CF
MATTA, KL
CARBOHYDRATE RESEARCH, 1992, 228 (01) : 243 - 253

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