RELATIONSHIP BETWEEN SUBSTANCE-P-INDUCED INITIAL TRANSIENT CONTRACTIONS AND INOSITOL PHOSPHOLIPID HYDROLYSIS IN GUINEA-PIG ILEUM

被引：5
|
作者：
HONDA, K [1 ]
TAKANO, Y [1 ]
YAMADA, A [1 ]
KAMIYA, H [1 ]
机构：
[1] FUKUOKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 81401,JAPAN
来源：
JOURNAL OF PHARMACOBIO-DYNAMICS | 1991年 / 14卷 / 07期
关键词：
SUBSTANCE-P; TACHYKININ PEPTIDE; SMOOTH MUSCLE; CONTRACTION; INOSITOL PHOSPHATE; PHOSPHOLIPASE-C; NEOMYCIN; CA2+ CHANNEL;
D O I：
10.1248/bpb1978.14.393
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of neomycin on substance P (SP)-induced inositol phospholipid hydrolysis and muscle contraction were studied in longitudinal smooth muscle of guinea pig ileum. Various tachykinin peptides including SP stimulated inositol phospholipid hydrolysis in guinea pig ileum. Neomycin (2.5 mM) reduced both the contractions and the accumulation of [H-3]inositol phosphates induced by SP. These results suggest that the initial transient contractions induced by SP are coupled to inositol phospholipid hydrolysis.
引用
收藏
页码：393 / 397
页数：5
相关论文
共 50 条
  • [31] SEPTIDE BUT NOT SUBSTANCE-P STIMULATES INHIBITORY NEURONS IN GUINEA-PIG ILEUM
    BURCHER, E
    STAMATAKOS, C
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 258 (03) : R9 - R10
  • [32] BLOCKADE OF HISTAMINE-INDUCED CONTRACTIONS OF GUINEA-PIG ILEUM BY BETA-HALOALKYLAMINES
    KENAKIN, TP
    COOK, DA
    [J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1976, 54 (03) : 386 - 392
  • [33] Effects of endotoxin-induced shock on withdrawal contractions in the guinea-pig isolated ileum
    Fatehi, M
    Tanomand, A
    Fatehi-Hassanabad, Z
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2002, 29 (07) : 608 - 611
  • [34] Constituents of Croton menthodorus and their effects on electrically induced contractions of the guinea-pig isolated ileum
    Capasso, A
    Piacente, S
    De Tommasi, N
    Ragucci, M
    Pizza, C
    [J]. PHYTOTHERAPY RESEARCH, 2000, 14 (03) : 156 - 159
  • [35] NEW ARYLOXYMETHYLACETOPHENONES - ANTAGONISTS OF LTD4-INDUCED CONTRACTIONS OF GUINEA-PIG ILEUM
    DILLARD, RD
    CARR, FP
    MCCULLOUGH, D
    HAISCH, KD
    RINKEMA, LE
    FLEISCH, JH
    [J]. FEDERATION PROCEEDINGS, 1985, 44 (03) : 491 - 491
  • [36] MUSCARINIC RECEPTOR MEDIATED INOSITOL PHOSPHOLIPID-METABOLISM IN GUINEA-PIG PAROTID-GLAND, ILEUM AND CORTEX
    EK, B
    NAHORSKI, SR
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, : 84 - 84
  • [37] RELATIONSHIP BETWEEN STIMULATED INOSITOL LIPID HYDROLYSIS AND CONTRACTILITY IN GUINEA-PIG VISCERAL LONGITUDINAL SMOOTH-MUSCLE
    BEST, L
    BROOKS, KJ
    BOLTON, TB
    [J]. BIOCHEMICAL PHARMACOLOGY, 1985, 34 (13) : 2297 - 2301
  • [38] EVIDENCE THAT AXONS CONTAINING SUBSTANCE-P IN THE GUINEA-PIG ILEUM ARE OF INTRINSIC ORIGIN
    FRANCO, R
    COSTA, M
    FURNESS, JB
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1979, 307 (01) : 57 - 63
  • [39] A NEW TACHYKININ RECEPTOR REVEALED BY SUBSTANCE-P ANALOGS IN THE GUINEA-PIG ILEUM
    PETITET, F
    BEAUJOUAN, JC
    SAFFROY, M
    TORRENS, Y
    LAVIELLE, S
    CHASSAING, G
    LOEUILLET, D
    GLOWINSKI, J
    [J]. COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES, 1992, 314 (07): : 299 - 303
  • [40] SUBSTANCE-P INDUCES ENDOGENOUS GABA RELEASE FROM GUINEA-PIG ILEUM
    TANIYAMA, K
    MIKI, Y
    KUSUNOKI, M
    SAITO, N
    TANAKA, C
    [J]. JAPANESE JOURNAL OF PHARMACOLOGY, 1984, 36 : P87 - P87
12345