EFFECT OF CHRONIC ETHANOL ON THE SEPTOHIPPOCAMPAL SYSTEM - A ROLE FOR NEUROTROPHIC FACTORS

被引：42
|
作者：
WALKER, DW [1 ]
HEATON, MB [1 ]
LEE, N [1 ]
KING, MA [1 ]
HUNTER, BE [1 ]
机构：
[1] GAINESVILLE VET ADM MED CTR,GAINESVILLE,FL
来源：
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1993年 / 17卷 / 01期
关键词：
CHRONIC ETHANOL EXPOSURE; ETHANOL NEUROTOXICITY; NEUROTROPHIC FACTORS; NEUROTROPHINS; HIPPOCAMPUS;
D O I：
10.1111/j.1530-0277.1993.tb00719.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The mechanisms by which chronic ethanol exposure produces neuronal damage have not been established. Potentially ethanol may reduce normal neurotrophic influences necessary for neuronal survival, growth, and function. We hypothesized that chronic ethanol exposure might produce a decrease in the synthesis, availability, upregulation, delivery, and/or the biological activity of normally occurring neurotrophic factors, or may alter the capacity of target neurons to respond to these factors. The available evidence leading to this hypothesis and supporting data from our laboratory are discussed.
引用
收藏
页码：12 / 18
页数：7
相关论文
共 50 条
  • [1] ALTERATIONS IN RESPONSIVENESS TO ETHANOL AND NEUROTROPHIC SUBSTANCES IN FETAL SEPTOHIPPOCAMPAL NEURONS FOLLOWING CHRONIC PRENATAL ETHANOL EXPOSURE
    HEATON, MB
    PAIVA, M
    SWANSON, DJ
    WALKER, DW
    [J]. DEVELOPMENTAL BRAIN RESEARCH, 1995, 85 (01): : 1 - 13
  • [2] Influence of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system
    Swanson, DJ
    Tonjes, L
    King, MA
    Walker, DW
    Heaton, MB
    [J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1996, 364 (01) : 104 - 112
  • [3] EFFECT OF CHRONIC STRESS ON THE SEPTOHIPPOCAMPAL CHOLINERGIC SYSTEM OF THE RAT
    TIZABI, Y
    GILAD, VH
    GILAD, GM
    [J]. NEUROENDOCRINOLOGY LETTERS, 1987, 9 (03) : 197 - 197
  • [4] The role of neurotrophic factors in regeneration of the nervous system
    Machalinski, Boguslaw
    Lazewski-Banaszak, Piotr
    Dabkowska, Elzbieta
    Paczkowska, Edyta
    Golab-Janowska, Monika
    Nowacki, Przemyslaw
    [J]. NEUROLOGIA I NEUROCHIRURGIA POLSKA, 2012, 46 (06) : 579 - 590
  • [5] Role of neurotrophic factors in adaptational processes of the nervous system
    Akoev G.N.
    Chalisova N.I.
    [J]. Neuroscience and Behavioral Physiology, 1997, 27 (3) : 207 - 211
  • [6] Acute Ethanol Exposure Elevates Muscarinic Tone in the Septohippocampal System
    Ericson, Mia
    Sama, Michelle A.
    Yeh, Hermes H.
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2010, 103 (01) : 290 - 296
  • [7] EFFECT OF NEUROMODULATION ON NEUROTROPHIC FACTORS IN PATIENTS WITH CHRONIC DISORDERS OF CONCIOUSNESS
    Iazeva, E. G.
    Legostaeva, L. A.
    Bakulin, I. S.
    Poydasheva, A. G.
    Abaimov, D. A.
    Suponeva, N. A.
    Shabalina, A. A.
    Ryabinkina, Y., V
    Piradov, M. A.
    [J]. BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY, 2020, (05): : 37 - 43
  • [8] CHRONIC PRENATAL ETHANOL EXPOSURE ALTERS THE NORMAL ONTOGENY OF CHOLINE-ACETYLTRANSFERASE ACTIVITY IN THE RAT SEPTOHIPPOCAMPAL SYSTEM
    SWANSON, DJ
    KING, MA
    WALKER, DW
    HEATON, MB
    [J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1995, 19 (05) : 1252 - 1260
  • [9] The role of neurotrophic factors in the development of the mammalian nervous system.
    Barbacid, M
    [J]. JOURNAL OF NEUROCHEMISTRY, 1996, 66 : S58 - S58
  • [10] A role of neurotrophic factors in epileptogenesis
    Lason, Wladystaw
    Budziszewska, Bogustawa
    Jaworska-Feil, Lucylla
    Leskiewicz, Monika
    Regulska, Magdalena
    Kusmider, Maciej
    Dziedzicka-Wasylewska, Marta
    [J]. PHARMACOLOGICAL REPORTS, 2007, 59 : 13 - 13
12345