MANGANESE SUPEROXIDE-DISMUTASE - NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF A CDNA-ENCODING A NEW HUMAN TRANSCRIPT

被引：47
|
作者：
CHURCH, SL
机构：
[1] Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MI
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1087卷 / 02期
关键词：
(Human); Amino acid sequence; cDNA cloning; Gene expression; Manganese enzyme; Superoxide dismutase;
D O I：
10.1016/0167-4781(90)90213-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three human cDNA libraries were screened with a human manganese superoxide dismutase (Mn-SOD) cDNA under moderately stringent conditions to characterize a large 4-6 kb RNA species which hybridizes to Mn-SOD in RNA blot analyses. A new 4.2 kb Mn-SOD cDNA clone (Mn-SOD 1) was isolated. Its long 3426 nucleotide 3′-untranslated sequence contains both of the 240 base 3′-untranslated sequences of the 1 kb Mn-SOD 4 and 5 cDNAs. This is a fully processed, cytoplasmic RNA species and raises the possibility of a role for particular 3′-untranslated sequence selection in Mn-SOD gene regulation. © 1990.
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页码：250 / 252
页数：3
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