The relevance of this research due to the fact that cybercrime is detrimental to the political, economic, social and information relations in the Russian Federation, causing enormous material damage. The purpose of a scientific article is the analysis of modern scientific approaches to the prevention of cybercrime in the Russian Federation and the production of an effective set of preventive measures to counter cybercrime. According to the authors, the purpose of the prevention of cybercrime acts as security in the Russian Federation, the necessary conditions for secure creation, processing and dissemination of computer information, as well as the normal functioning of computer devices and information and telecommunication networks. Subject to the methodological approach of criminological science, the authors highlighted the measures of General prevention and special preventive measures of cybercrime. To special measures to prevent cybercrimes proposed include: improvement of the existing criminal law, criminal procedure and information legislation; improvement of the judicial practice; training in educational establishments of the required number of specialists in the sphere of information security; the establishment in Universities and research institutes research laboratories on the development of hardware and software systems computer security; consolidation in the employment contracts (contracts) provisions on the criminal liability of persons for the disclosure of sensitive information about the system of protection of proprietary information; continuous monitoring of managers for the installation and upgrading of computer security in state and municipal organizations; the creation in Russia of a national operating system for computing devices and systems for fixation, identification of crimes in the sphere of computer information and computer criminals; the creation of new and improvement of existing methods of detecting cybercrimes involving experts in the field of information security. The list of measures for the prevention of cybercrime can be extended, but, no doubt, only an integrative and comprehensive approaches in the application of law enforcement preventive measures to improve the level of information security of Russia and the efficiency of prevention of cybercrimes.