Health care workers' psychological well-being programs, including the prevention of burnout, from the very early stages of their medical career, is becoming an increasingly important task of the personnel management policy in the health care system. Aim. To determine the burnout prevalence among resident physicians studying in the Russian Federation. Materials and methods. The paper presents the results of the nationwide survey in which 434 respondents involved in 56 specialties of residency training took part. The median age of the respondents was 25 [24-26] (Me [Q(1) -Q(3)]) years old. Within the framework of the survey the method of diagnostics of emotional burnout syndrome Maslach K., Jackson S. (MBI), adapted by Vodopyanova N.E. and Starchenkova E.S., Hospital Anxiety and Depression Scale (HADS), as well as questions aimed at determining the factors associated with the burnout in resident physicians were used. Results. The results of the study showed that most residents (85,5%) were diagnosed with high and extremely high levels of burnout; 70.5% of respondents had high levels of anxiety, and 54,3% were diagnosed with depression of varying degrees of severity. The factors associated with the presence of burnout were female gender, difficult financial situation, smoking and alcohol consumption, insomnia, poor health, low commitment to the profession of a medical worker, lack of support from colleagues, monotonous work tasks and lack of prospects for career development. Conclusion. Identification, description as well as further correction of potentially modifiable factors associated with burnout of residents is an important part of planning a new personnel strategy of healthcare system, where one of the most important elements is protection of psychological well-being of medical workers and psychological support of their clinical practice.