COMPARISON OF RIGID AND FLEXIBLE BACKBONES IN ANTISENSE OLIGONUCLEOTIDES

被引：29
|
作者：
DEMESMAEKER, A
WALDNER, A
SANGHVI, YS
LEBRETON, J
机构：
[1] ISIS PHARMACEUT,CARLSBAD,CA 92008
[2] CIBA GEIGY AG,CENT RES LABS,CH-4002 BASEL,SWITZERLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 03期
关键词：
D O I：
10.1016/0960-894X(94)80003-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Stepwise restriction of free rotation, as well as introduction of positive charges in the internucleosidic linkage are factors which can positively influence the thermal melting behaviour of the corresponding duplexes formed between modified DNA and their RNA complement. By correct positioning of the rigidity within backbone, it is possible to achieve even higher binding affinity (T-m's) than with natural oligodeoxy-ribonucleotides (ODNs).
引用
收藏
页码：395 / 398
页数：4
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