GENE MANIPULATION BY PROTOPLAST FUSION AND PENICILLIN PRODUCTION BY PENICILLIUM-CHRYSOGENUM

被引：7
|
作者：
TAHOUN, MK
机构：
[1] Department of Agricultural Industries, Faculty of Agriculture, University of Alexandria
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 1993年 / 39卷
关键词：
PENICILLIUM-CHRYSOGENUM; HYBRIDIZATION; SEGREGATION; PENICILLIN YIELDS;
D O I：
10.1007/BF02919009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hybrids have been obtained by protoplast fusion of nitrate-non-utilizing cnx- and acetate-nonutilizing fac- mutants of Penicillium chrysogenum strains 4/95 and 26/818, respectively. Induced haplodization of the hybrids allowed the recovery of stable segregants, which were screened for penicillin production. The penicillin-producing segregants showed a wide range of titers that reached for a certain mutant to 290-390% increase above the parent strains.
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页码：445 / 453
页数：9
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