ANTITUMOR-ACTIVITY OF LOW-TOXICITY LIPOPOLYSACCHARIDE OF BORDETELLA-PERTUSSIS

被引：12
|
作者：
OHNISHI, M
KIMURA, S
YAMAZAKI, M
OSHIMA, H
MIZUNO, DI
ABE, S
YAMAGUCHI, H
机构：
[1] TEIKYO UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ITABASHI KU,TOKYO 173,JAPAN
[2] TEIKYO UNIV,FAC PHARMACEUT SCI,SAGAMIKO,KANAGAWA 19901,JAPAN
[3] TEIKYO UNIV,BIOTECHNOL RES CTR,KAWASAKI,KANAGAWA,JAPAN
来源：
BRITISH JOURNAL OF CANCER | 1994年 / 69卷 / 06期
关键词：
D O I：
10.1038/bjc.1994.204
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As parr of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.
引用
收藏
页码：1038 / 1042
页数：5
相关论文
共 50 条
  • [41] BORDETELLA-PERTUSSIS INDUCES RESPIRATORY BURST ACTIVITY IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES
    STEED, LL
    AKPORIAYE, ET
    FRIEDMAN, RL
    INFECTION AND IMMUNITY, 1992, 60 (05) : 2101 - 2105
  • [42] ANTIGENIC ACTIVITY OF BORDETELLA-PERTUSSIS DURING CULTIVATION IN FLUID NUTRIENT MEDIA
    MIRYASOVA, LV
    MOSHIASHVILI, IY
    BASNAKYAN, IA
    SERGEEV, VV
    ZAPOROZHTSEV, LN
    FILINA, GT
    ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII, 1978, (06): : 31 - 36
  • [43] ADENYLATE-CYCLASE ACTIVITY DURING PHENOTYPIC VARIATION OF BORDETELLA-PERTUSSIS
    BROWNLIE, RM
    COOTE, JG
    PARTON, R
    JOURNAL OF GENERAL MICROBIOLOGY, 1985, 131 (JAN): : 27 - 38
  • [44] EXPERIMENTAL ANTITUMOR-ACTIVITY AND TOXICITY OF ESPERAMICIN, A NEW ANTITUMOR ANTIBIOTIC
    SCHURIG, JE
    ROSE, WC
    KAMEI, H
    FLORCZYK, AP
    NISHIYAMA, Y
    FARWELL, AR
    BRADNER, WT
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1987, 28 : 310 - 310
  • [45] EFFECT OF ANTIBIOTICS ON BORDETELLA-PERTUSSIS ADHERING ACTIVITY - HYPOTHESIS REGARDING MECHANISM OF ACTION
    SCAGLIONE, F
    DEMARTINI, G
    DUGNANI, S
    FERRARA, F
    MACCARINELLI, G
    COCUZZA, C
    FRASCHINI, F
    CHEMOTHERAPY, 1994, 40 (03) : 215 - 220
  • [46] MODULATION OF INVASIVENESS AND CATALYTIC ACTIVITY OF BORDETELLA-PERTUSSIS ADENYLATE-CYCLASE BY POLYCATIONS
    RAPTIS, A
    KNIPLING, LG
    GENTILE, F
    WOLFF, J
    INFECTION AND IMMUNITY, 1989, 57 (04) : 1066 - 1071
  • [47] HEMOLYTIC-ACTIVITY OF ADENYLATE-CYCLASE TOXIN FROM BORDETELLA-PERTUSSIS
    EHRMANN, IE
    GRAY, MC
    GORDON, VM
    GRAY, LS
    HEWLETT, EL
    FEBS LETTERS, 1991, 278 (01) : 79 - 83
  • [48] EFFECT OF METHYL-CYCLODEXTRIN ON ADENYLATE-CYCLASE ACTIVITY OF BORDETELLA-PERTUSSIS
    HOZBOR, DF
    SAMO, A
    YANTORNO, OM
    WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 1991, 7 (03): : 309 - 315
  • [49] PLEURORRHEA-INDUCING ACTIVITY OF THE HISTAMINE-SENSITIZING FACTOR OF BORDETELLA-PERTUSSIS
    ENDOH, M
    FUJIMOTO, T
    NAKASE, Y
    MICROBIOLOGY AND IMMUNOLOGY, 1983, 27 (11) : 979 - 984
  • [50] HEPARIN-INHIBITABLE LECTIN ACTIVITY OF THE FILAMENTOUS HEMAGGLUTININ ADHESIN OF BORDETELLA-PERTUSSIS
    MENOZZI, FD
    MUTOMBO, R
    RENAULD, G
    GANTIEZ, C
    HANNAH, JH
    LEININGER, E
    BRENNAN, MJ
    LOCHT, C
    INFECTION AND IMMUNITY, 1994, 62 (03) : 769 - 778
12345