ANTITUMOR-ACTIVITY OF LOW-TOXICITY LIPOPOLYSACCHARIDE OF BORDETELLA-PERTUSSIS

被引：12
|
作者：
OHNISHI, M
KIMURA, S
YAMAZAKI, M
OSHIMA, H
MIZUNO, DI
ABE, S
YAMAGUCHI, H
机构：
[1] TEIKYO UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,ITABASHI KU,TOKYO 173,JAPAN
[2] TEIKYO UNIV,FAC PHARMACEUT SCI,SAGAMIKO,KANAGAWA 19901,JAPAN
[3] TEIKYO UNIV,BIOTECHNOL RES CTR,KAWASAKI,KANAGAWA,JAPAN
来源：
BRITISH JOURNAL OF CANCER | 1994年 / 69卷 / 06期
关键词：
D O I：
10.1038/bjc.1994.204
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A lipopolysaccharide (BP-LPS) isolated from killed Bordetella pertussis (Tohama strain) was determined to have low toxicity based on the mortality and decrease in body weight of BP-LPS-injected mice. BP-LPS, administered intradermally or intraperitoneally, clearly inhibited the growth of an MM46 murine mammary carcinoma. When compared with a toxic Escherichia coli-derived LPS, BP-LPS displayed excellent anti-tumour activity against MH134 hepatoma and Meth A fibrosarcoma. As parr of a combined chemotherapy/immunotherapy regimen, BP-LPS also seemed to prolong the lifespan of mice inoculated with Lewis lung carcinoma. BP-LPS thus appears to have valuable characteristics as an anti-tumour agent.
引用
收藏
页码：1038 / 1042
页数：5
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