OVARIAN-CYST FORMATION IN 2 PREMENOPAUSAL PATIENTS TREATED WITH TAMOXIFEN FOR BREAST-CANCER

被引：26
|
作者：
SHULMAN, A [1 ]
COHEN, I [1 ]
ALTARAS, MM [1 ]
MAYMON, R [1 ]
BENNUN, I [1 ]
TEPPER, R [1 ]
BEYTH, Y [1 ]
机构：
[1] TEL AVIV UNIV,ASSAF HAROFE HOSP,SACKLER SCH MED,DEPT OBSTET & GYNAECOL,RAMAT AVIV,ISRAEL
来源：
HUMAN REPRODUCTION | 1994年 / 9卷 / 08期
关键词：
BREAST CANCER; GNRH; ESTROGENS; PRE-MENOPAUSE; TAMOXIFEN;
D O I：
10.1093/oxfordjournals.humrep.a138723
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Pre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.
引用
收藏
页码：1427 / 1429
页数：3
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