THE LIVER-INJURY AND THE LIPID-PEROXIDATION IN MICE BY TRICHLOROACETIC-ACID OR TRICHLOROETHYLENE

The possibility that the hepatic toxicity of trichloroethylene (TCE) relates to the increase of lipid peroxide in the liver is investigated. When 0.12 mmol/kg, 0.6 mmol/kg or 1.2 mmol/kg of trichloroacetic acid (TCA) or TCE was administered to a mouse at a single dose, the content of thiobarbituric acid reactive substances in the liver increased in a dependent manner, while the contents of flavin and GSH, and the activity of mitochondrial ATP synthesis in the liver decreased. There was a significant correlation between these parameters. These results suggest that the lipid peroxidation and the decrease of mitochondrial ATP synthesis in the liver of mice caused by TCA or TCE relate to the liver injury.