CD8 IS NEEDED FOR DEVELOPMENT OF CYTOTOXIC T-CELLS BUT NOT HELPER T-CELLS

被引：488
|
作者：
FUNGLEUNG, WP
SCHILHAM, MW
RAHEMTULLA, A
KUNDIG, TM
VOLLENWEIDER, M
POTTER, J
VANEWIJK, W
MAK, TW
机构：
[1] UNIV TORONTO, DEPT MED BIOPHYS, TORONTO M4X 1K9, ONTARIO, CANADA
[2] UNIV TORONTO, DEPT IMMUNOL, TORONTO M4X 1K9, ONTARIO, CANADA
[3] UNIV ZURICH, INST PATHOL, CH-8006 ZURICH, SWITZERLAND
[4] ERASMUS UNIV, DEPT IMMUNOL, 3000 DR ROTTERDAM, NETHERLANDS
来源：
CELL | 1991年 / 65卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0092-8674(91)90462-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mice, CD8+ T lymphocytes are not present in peripheral lymphoid organs, but the CD4+ T lymphocyte population seems to be unaltered. Cytotoxic response of T lymphocytes from these mice against alloantigens and viral antigens is dramatically decreased. Proliferative response against alloantigens and in vivo help to B lymphocytes, however, are not affected. These data suggest that CD8 is necessary for the maturation and positive selection of class I MHC restricted cytotoxic T lymphocytes but is not required on any of the intermediate thymocyte populations (CD8+CD4-TcR- or CD4+CD8+TcR(low)) during the development of functional class II MHC restricted helper T cells.
引用
收藏
页码：443 / 449
页数：7
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