ON THE RAT MODEL OF HUMAN OSTEOPENIAS AND OSTEOPOROSIS

被引：372
|
作者：
FROST, HM
JEE, WSS
机构：
[1] UNIV UTAH, SCH MED, DIV RADIOBIOL, BLDG 586, SALT LAKE CITY, UT 84112 USA
[2] SO COLORADO CLIN, DEPT ORTHOPAED SURG, PUEBLO, CO USA
来源：
BONE AND MINERAL | 1992年 / 18卷 / 03期
关键词：
RAT; OSTEOPOROSIS; OSTEOPENIA; BONE MODELING; BONE REMODELING; MECHANICAL AND NONMECHANICAL AGENTS;
D O I：
10.1016/0169-6009(92)90809-R
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.
引用
收藏
页码：227 / 236
页数：10
相关论文
共 50 条
  • [21] Raman spectroscopy as a predictive tool for monitoring osteoporosis therapy in a rat model of postmenopausal osteoporosis
    J. Renwick Beattie
    Antonia Sophocleous
    M. Clare Caraher
    Olive O’Driscoll
    Niamh M. Cummins
    Steven E. J. Bell
    Mark Towler
    Alireza Rahimnejad Yazdi
    Stuart H. Ralston
    Aymen I. Idris
    Journal of Materials Science: Materials in Medicine, 2019, 30
  • [22] Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial
    Kraljevic Pavelic, Sandra
    Micek, Vedran
    Bobinac, Dragica
    Bazdulj, Edo
    Gianoncelli, Alessandra
    Krpan, Dalibor
    Zuvic, Marta
    Eisenwagen, Sandra
    Stambrook, Peter J.
    Pavelic, Kresimir
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 246 (05) : 529 - 537
  • [23] Efficacy of Human Adipose-Derived Stem Cells in Spinal Fusion in a Rat Ovariectomy Osteoporosis Model
    Na, Min Kyun
    Bae, In-Suk
    Yi, Hyeong-Joong
    Do, Byung-Rok
    Kim, Kee D.
    Chun, Hyoung-Joon
    TURKISH NEUROSURGERY, 2022, 32 (02) : 251 - 260
  • [24] Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis
    Fathilah, Siti Noor
    Abdullah, Shahrum
    Mohamed, Norazlina
    Shuid, Ahmad Nazrun
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 2012
  • [25] Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals
    Zhu, Junxiong
    Zhang, Chenggui
    Jia, Jialin
    Wang, Hong
    Leng, Huijie
    Xu, Yingsheng
    Wu, Cuishuan
    Zhang, Qiang
    Song, Chunli
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2021, 1487 (01) : 31 - 42
  • [26] Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis
    Cao, Hong
    Zhang, Ying
    Qian, Wei
    Guo, Xiho-Peng
    Sun, Chen
    Zhang, Lei
    Cheng, Xin-Hua
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 13 (05) : 2399 - 2404
  • [27] EFFECTS OF TESTOSTERONE IN A RAT MODEL OF OSTEOPOROSIS COMBINING DISUSE AND ORCHIDECTOMY
    Blouin, S.
    Libouban, H.
    Moreau, M.
    Audran, M.
    Chappard, D.
    CALCIFIED TISSUE INTERNATIONAL, 2004, 74 : S103 - S103
  • [28] Effects of a New Conjugate Drug in a Rat Model of Postmenopausal Osteoporosis
    Liu, Careesa
    Young, Robert
    Grynpas, Marc
    JOURNAL OF BONE AND MINERAL RESEARCH, 2013, 28
  • [29] CHANGES IN SKELETAL MASS AND FRAGILITY WITH CASTRATION IN RAT - A MODEL OF OSTEOPOROSIS
    SAVILLE, PD
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1969, 17 (02) : 155 - &
  • [30] THE RAT AS AN ANIMAL-MODEL FOR THE STUDY OF SENILE IDIOPATHIC OSTEOPOROSIS
    SIMON, MR
    ACTA ANATOMICA, 1984, 119 (04): : 248 - 250
12345