INVITRO TOXICITY ASSESSMENT OF CYCLOSPORINE-A AND ITS ANALOGS IN A PRIMARY RAT HEPATOCYTE CULTURE MODEL

被引:34
|
作者
BOELSTERLI, UA [1 ]
BOUIS, P [1 ]
BROUILLARD, JF [1 ]
DONATSCH, P [1 ]
机构
[1] SANDOZ LTD,DEPT TOXICOL,DRUG,SAFETY ASSESSMENT,CH-4002 BASEL,SWITZERLAND
关键词
D O I
10.1016/0041-008X(88)90081-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:212 / 221
页数:10
相关论文
共 50 条
  • [21] Development of an in vitro liver toxicity prediction model based on long term primary rat hepatocyte cell culture
    Hrach, Jens
    Hewitt, Philip
    [J]. TOXICOLOGY LETTERS, 2008, 180 : S122 - S122
  • [22] PRIMARY HEPATOCYTE CULTURE AS AN ACTIVATING SYSTEM FOR XENOBIOTICA TESTED IN THE RAT WHOLE EMBRYO INVITRO
    BECHTER, R
    BOUIS, P
    FISCHER, V
    [J]. IN VITRO TOXICOLOGY : NEW DIRECTIONS, 1989, 7 : 313 - 326
  • [23] THE EFFECT OF CYCLOSPORINE-A INVITRO ON MEMBRANE FUNCTIONS OF RAT-KIDNEY MITOCHONDRIA
    STRZELECKI, T
    MENON, M
    KHAULI, R
    KUMAR, S
    [J]. CLINICAL RESEARCH, 1986, 34 (02): : A610 - A610
  • [24] Fish primary hepatocyte culture; An important model for xenobiotic metabolism and toxicity studies
    Pesonen, M
    Andersson, TB
    [J]. AQUATIC TOXICOLOGY, 1997, 37 (2-3) : 253 - 267
  • [25] IS THE CYCLOSPORINE-A TOXICITY ON RAT PANCREATIC B-CELLS MODULATED BY THE MHC
    HAHN, HJ
    LAUBE, R
    KLOTING, I
    [J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, 1989, 93 (2-3): : 203 - 207
  • [26] IMPORTANCE OF ENDOGENOUS PROSTAGLANDINS FOR THE TOXICITY OF CYCLOSPORINE-A TO RAT ENDOCRINE AND EXOCRINE PANCREAS
    RUNZI, M
    PESKAR, BM
    VONSCHONFELD, J
    MULLER, MK
    [J]. GUT, 1992, 33 (11) : 1572 - 1577
  • [27] EFFECT OF INVITRO CULTURE AND CYCLOSPORINE-A TREATMENT ON ADRENAL-MEDULLA ALLOGRAFT SURVIVAL
    RICORDI, C
    CRYER, PE
    LACY, PE
    [J]. JOURNAL OF SURGICAL RESEARCH, 1989, 47 (01) : 20 - 23
  • [28] HUMAN HEPATOCYTE PRIMARY CULTURES IN TOXICITY ASSESSMENT
    BRAMBILLA, G
    MARTELLI, A
    [J]. CYTOTECHNOLOGY, 1993, 11 : 6 - 8
  • [29] COMPARISON OF CYCLOSPORINE G TO CYCLOSPORINE-A IN A HETEROTOPIC RAT-HEART TRANSPLANT MODEL
    LIU, WX
    HIGGINS, RSD
    LETSOU, GV
    DETMER, WM
    CONDOS, SG
    FRANCO, KL
    BALDWIN, JC
    [J]. FASEB JOURNAL, 1991, 5 (06): : A1637 - A1637
  • [30] COMPARATIVE-STUDY OF THE ANTIALLERGIC AND IMMUNOSUPPRESSIVE ACTIVITIES OF CYCLOSPORINE-A AND SOME OF ITS ANALOGS
    EZEAMUZIE, CI
    ASSEM, ESK
    BAHL, AK
    [J]. AGENTS AND ACTIONS, 1992, : C275 - C278