INVITRO TOXICITY ASSESSMENT OF CYCLOSPORINE-A AND ITS ANALOGS IN A PRIMARY RAT HEPATOCYTE CULTURE MODEL

被引:34
|
作者
BOELSTERLI, UA [1 ]
BOUIS, P [1 ]
BROUILLARD, JF [1 ]
DONATSCH, P [1 ]
机构
[1] SANDOZ LTD,DEPT TOXICOL,DRUG,SAFETY ASSESSMENT,CH-4002 BASEL,SWITZERLAND
关键词
D O I
10.1016/0041-008X(88)90081-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:212 / 221
页数:10
相关论文
共 50 条
  • [1] CYCLOSPORINE-A - EFFECTIVENESS AND TOXICITY IN A RAT MODEL
    DIEPERINK, H
    KEMP, E
    LEYSSAC, PP
    STARKLINT, H
    [J]. CLINICAL NEPHROLOGY, 1986, 25 : S46 - S50
  • [2] RENAL TOXICITY OF CYCLOSPORINE-A IN THE RAT
    THIEL, G
    DEROUGEMONT, D
    TORHORST, J
    BRUNNER, FP
    [J]. KIDNEY INTERNATIONAL, 1981, 20 (01) : 141 - 142
  • [3] CYCLOSPORINE-A TOXICITY FOR VASCULARIZED PANCREATIC TRANSPLANTATION IN THE RAT
    OTSU, I
    KITANO, N
    TAMINATO, T
    FUJIYA, H
    NOZAWA, M
    [J]. TRANSPLANTATION PROCEEDINGS, 1987, 19 (01) : 1252 - 1256
  • [4] ASSESSMENT OF CYCLOSPORINE-A INTERACTIONS WITH HUMAN PLASMA-LIPOPROTEINS INVITRO AND INVIVO IN THE RAT
    URIEN, S
    ZINI, R
    LEMAIRE, M
    TILLEMENT, JP
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1990, 253 (01): : 305 - 309
  • [5] NEPHROTOXICITY OF CYCLOSPORINE-A AND CYCLOSPORINE-G IN A RAT MODEL
    TEJANI, A
    LANCMAN, I
    POMRANTZ, A
    KHAWAR, M
    CHEN, C
    [J]. TRANSPLANTATION, 1988, 45 (01) : 184 - 187
  • [6] COMPARISON OF THE INVITRO IMMUNOSUPPRESSIVE EFFECTS OF CYCLOSPORINE-A AND ITS METABOLITES
    COPELAND, KR
    YATSCOFF, RW
    RUSH, D
    JEFFERY, JR
    [J]. TRANSPLANTATION PROCEEDINGS, 1989, 21 (01) : 1449 - 1452
  • [7] ALLOGENEIC INTRASPLENIC HEPATOCYTE TRANSPLANTATION IN THE GUNN RAT USING CYCLOSPORINE-A IMMUNOSUPPRESSION
    COBOURN, CS
    MAKOWKA, L
    FALK, JA
    FALK, RE
    [J]. TRANSPLANTATION PROCEEDINGS, 1987, 19 (01) : 1002 - 1003
  • [8] DISRUPTION OF CANALICULAR FUNCTION IN ISOLATED RAT HEPATOCYTE COUPLETS CAUSED BY CYCLOSPORINE-A
    ROMAN, ID
    COLEMAN, R
    [J]. BIOCHEMICAL PHARMACOLOGY, 1994, 48 (12) : 2181 - 2188
  • [9] Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture
    Hrach, J.
    Mueller, S. O.
    Hewitt, P.
    [J]. TOXICOLOGY LETTERS, 2011, 206 (02) : 189 - 196
  • [10] A primary canine hepatocyte culture model for analysis of cellular toxicity and inflamation
    Au, A. Y.
    Hasenwinkel, J. M.
    Frondoza, C. G.
    [J]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 2008, 22 (03) : 806 - 807