LYMPHOCYTE GLUCOCORTICOID RECEPTOR-BINDING DURING DEPRESSION AND AFTER CLINICAL RECOVERY

被引：12

作者：

RUPPRECHT, R ^{[1
]}

KORNHUBER, J ^{[1
]}

WODARZ, N ^{[1
]}

LUGAUER, J ^{[1
]}

GOBEL, C ^{[1
]}

RIEDERER, P ^{[1
]}

BECKMANN, H ^{[1
]}

机构：

[1] UNIV WURZBURG, DEPT PSYCHIAT, W-8700 WURZBURG, GERMANY

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1991年 / 22卷 / 1-2期

关键词：

GLUCOCORTICOID RECEPTORS; BINDING; DEPRESSION; ANTIDEPRESSANTS;

D O I：

10.1016/0165-0327(91)90080-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lymphocyte glucocorticoid receptor binding parameters were studied in 15 severely depressed patients during depression and after clinical recovery, and in 15 healthy controls. There was no difference in glucocorticoid receptor number or affinity between depressed patients and recovered or control subjects. Afternoon ACTH and cortisol concentrations did not differ significantly between the three groups. No relationship could be established between glucocorticoid receptor binding and antidepressant medication. These data support the view of an impaired ligand-induced plasticity of glucocorticoid receptor regulation rather than the hypothesis of decreased glucocorticoid receptor numbers during depression.

引用

下载

页码：31 / 35

页数：5

共 50 条

[11] Glucocorticoid receptor-binding characteristics in severe asthma
Bonnans, C
Chanez, P
Meziane, H
Godard, P
Bousquet, J
Vachier, I
EUROPEAN RESPIRATORY JOURNAL, 2003, 21 (06) : 985 - 988
[12] GLUCOCORTICOID REGULATION OF HIPPOCAMPAL OXYTOCIN RECEPTOR-BINDING
LIBERZON, I
CHALMERS, DT
MANSOUR, A
LOPEZ, JF
WATSON, SJ
YOUNG, EA
BRAIN RESEARCH, 1994, 650 (02) : 317 - 322
[13] SPECIFIC GLUCOCORTICOID RECEPTOR-BINDING TO DNA RECONSTITUTED IN A NUCLEOSOME
PERLMANN, T
WRANGE, O
EMBO JOURNAL, 1988, 7 (10): : 3073 - 3079
[14] INFLUENCE OF PROTEINASE-INHIBITORS ON GLUCOCORTICOID RECEPTOR-BINDING
HUBBARD, JR
BARRETT, A
KALIMI, M
BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 798 (02) : 187 - 191
[15] ALTERED GLUCOCORTICOID RECEPTOR-BINDING IN ATOPIC-DERMATITIS
CLAYTON, MH
LEUNG, DYM
SURS, W
SZEFLER, SJ
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1995, 96 (03) : 421 - 423
[16] INTERACTION OF HISTONES IN GLUCOCORTICOID RECEPTOR-BINDING TO DNA INVITRO
ISOHASHI, F
OKAMOTO, K
UEDA, K
KOKUFU, I
YOSHIKAWA, K
SAKAMOTO, Y
CANCER RESEARCH, 1989, 49 (08) : S2235 - S2237
[17] Identification and characterization of glucocorticoid receptor-binding sites in the human genome
Taniguchi-Yanai, Keiko
Koike, Yoshiko
Hasegawa, Takashi
Furuta, Yuichi
Serizawa, Masakuni
Ohshima, Noriko
Kato, Norihiro
Yanai, Kazuyuki
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2010, 30 (02) : 88 - 105
[18] PHORONE (DIISOPROPYLIDENE ACETONE) DECREASES GLUCOCORTICOID RECEPTOR-BINDING INVIVO
SUNAHARA, GI
GRIEU, F
CHIESA, A
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (04) : 1512 - 1513
[19] INVITRO AND EXVIVO GLUCOCORTICOID RECEPTOR-BINDING OF DEFLAZACORT AND PREDNISOLONE IN THE RAT
BARONE, D
LUZZANI, F
GLASSER, A
CALCIFIED TISSUE INTERNATIONAL, 1982, 34 (06) : 588 - 588
[20] GLUCOCORTICOID-RECEPTOR INTERACTIONS - DISCRIMINATION BETWEEN GLUCOCORTICOID AGONISTS AND ANTAGONISTS BY MEANS OF RECEPTOR-BINDING KINETICS
JONES, TR
BELL, PA
BIOCHEMICAL JOURNAL, 1982, 204 (03) : 721 - 729

← 1 2 3 4 5 →