ETHANOL INHIBITION OF N-METHYL-D-ASPARTATE-ACTIVATED ION CURRENT IN RAT HIPPOCAMPAL-NEURONS IS NOT COMPETITIVE WITH GLYCINE

被引：82
|
作者：
PEOPLES, RW
WEIGHT, FF
机构：
[1] Section of Electrophysiology, Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville
来源：
BRAIN RESEARCH | 1992年 / 571卷 / 02期
关键词：
N-METHYL-D-ASPARTATE; ETHANOL; GLYCINE; HIPPOCAMPUS; RAT;
D O I：
10.1016/0006-8993(92)90674-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The interaction of ethanol with glycine at the N-methyl-D-aspartate (NMDA)-activated ion channel was investigated in voltage-clamped rat cultured hippocampal neurons. As shown previously, glycine increased, and ethanol inhibited, the NMDA-activated current in these cells. Concentration-response data for glycine (0.1-100-mu-M) indicate that the inhibition of NMDA-activated current by ethanol does not involve a competitive interaction with glycine. Thus, ethanol appears to inhibit NMDA-activated current at a locus different from the glycine modulatory site.
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页码：342 / 344
页数：3
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