MEGAKARYOBLASTIC LEUKEMIA WITH AN N-RAS MUTATION AND LATE ACQUISITION OF A PHILADELPHIA-CHROMOSOME

被引：0

作者：

VANDENBERGHE, E

MARTIAT, P

BAENS, M

STUL, M

FERRANT, A

CUNEO, A

CASSIMAN, JJ

MECUCCI, C

VANDENBERGHE, H

机构：

[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,HERESTR 49,B-3000 LOUVAIN,BELGIUM

[2] POLICLIN MONTELUCE,IST EMATOL,PERUGIA,ITALY

[3] CATHOLIC UNIV LEUVEN,DEPT HEMATOL,B-3000 LOUVAIN,BELGIUM

[4] UNIV FERRARA,CATTEDRA EMATOL,I-44100 FERRARA,ITALY

来源：

LEUKEMIA | 1991年 / 5卷 / 08期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient is described with de novo acute non-lymphocytic leukemia of megakaryoblastic lineage with trilineage myelodysplasia. This patient was studied cytogenetically and using molecular genetic techniques throughout her clinical course. She had an N-ras mutation at diagnosis which persisted despite a bone marrow transplant, and acquired a Philadelphia chromosome associated with a P190 BCR-ABL transcript at clinical relapse 3 months post-transplantation.

引用

页码：683 / 686

页数：4

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