A Novel Catalytic Synthesis of Flavones under Autoclave Conditions and Comparative Study of Anti-cancer Activity

被引:1
|
作者
Rajeshbabu, K. [1 ]
Pushpalatha, S. [2 ]
Ramakrishna, B. [2 ]
Madhavarao, V. [1 ]
机构
[1] Acharya Nagarjuna Univ, Bapatla Engn Coll Autonomous, Dept Chem, Guntur 522101, India
[2] St Marys Pharm Coll, Hyderabad, Andhra Pradesh, India
来源
BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH | 2016年 / 9卷 / 01期
关键词
Autoclave conditions; 2; 4; 6-tri methyl pyridine; KIO3; flavones; cytotoxic activity;
D O I
10.9734/BJPR/2016/15884
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Novel, less toxic, more effective catalysts were used to synthesize various flavones under auto clave conditions. Substituted o-hydroxyl acetophenones and benzaldehydes were reacted in presence of 2, 4, 6-trimethylpyridine, a pinch of TiCl4 and yielded chalcones. Equimolar ratio of KIO3, KI, and H2SO4 was used as in situ catalytic source for I-2 to convert chalcones to flavones. The progress of the reactions was monitored by TLC. Crude compounds were recrystallized from methyl alcohol. We obtained good yields of products within less time periods. We had gone through IR, HNMR, Elemental analysis and mass data to characterize the compounds. Selective compounds were screened for cytotoxic activity against A549 human tumour cell lines by MTT method and comparative study has been done.
引用
收藏
页数:7
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