EFFECT OF CHLORPROMAZINE ON PROLINE ABSORPTION ACROSS RAT JEJUNUM

被引：0
|
作者：
NASSAR, CF
ABDALLAH, LE
KARKAJI, EG
机构：
[1] Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut
来源：
PHARMACOLOGICAL RESEARCH | 1991年 / 24卷 / 01期
关键词：
CHLORPROMAZINE; PROLINE; INTESTINAL ABSORPTION;
D O I：
10.1016/1043-6618(91)90064-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of chlorpromazine on proline absorption across jejunum in anaesthetized rats was investigated. Intravenous infusion of chlorpromazine reduced significantly (P<0.01) proline absorption across the jejunum. Intraluminal perfusion of chlorpromazine into the jejunal segment reversed net absorption of proline to net secretion. Net water absorption was increased significantly (P<0.01) when chlorpromazine was infused intravenously or perfused intraluminally. Unidirectional influx of proline across the mucosal surface was significantly inhibited (P<0.01) after preincubation with 1 mm chlorpromazine. © 1991 The Italian Pharmacological Society.
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收藏
页码：53 / 57
页数：5
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