SYNTHESIS OF 2,3-DIHYDRO-IMIDAZO[1,2-C]PYRIMIDO[5',4'-4,5]THIEN[2,3-E]PYRIMIDINES AND 2H-3,4-DIHYDRO-PYRIMIDO[1,2-C]PYRIMIDO[5',4'-4,5]THIENO[2,3-E]PYRIMIDINES

被引：0

作者：

WAGNER, G ^{[1
]}

VIEWEG, H ^{[1
]}

LEISTNER, S ^{[1
]}

机构：

[1] UNIV LEIPZIG,FACHBEREICH BIOWISSENSCH,O-7010 LEIPZIG,GERMANY

来源：

PHARMAZIE | 1993年 / 48卷 / 08期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of dibenzoyldiacetonitrile with cyanothioacetamide gave 5-cyano-6-methyl-2-phenyl-pyri-mid-4(3H)-thione (4) in good yield. The title compounds were synthesized on two different routes. On one way, 3-amino-thieno[2,3-d]pyrimidine-2-carbonic acid alkylesters obtained from 4 were after acetylation of the amino group to 9 transformed by reaction of aminoethanol to the hydroxy ethylated pyrimidothienopyrimidone 10b. This compound after chlorination to 11 by reaction with 1,2-diaminoethan or 1,3-diaminopropan yielded the desired tetracyclic substances 12 and 13. On the other way, 3-aminothieno[2,3-d]pyrimidine-2-carboxamide 14 obtained from 4 gave via the pyrimidothienopyrimidone 15, the chloro compound 17 and the omega-hydroxyalkyl compounds 21 and 22 the title substances 23 and 24.

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页码：588 / 591

页数：4

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