DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

被引：2014
|
作者：
LIU, LF
机构：
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 1989年 / 58卷
关键词：
D O I：
10.1146/annurev.bi.58.070189.002031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：351 / 375
页数：25
相关论文
共 50 条
  • [21] Conformation and mechanism in DNA-topoisomerase I as a target of antitumor drugs: Optical spectroscopy approach
    Fleury, F
    Ianoul, A
    Kudelina, I
    Bronstein, I
    Alix, AJP
    Dodson, G
    Feofanov, A
    Nabiev, I
    SPECTROSCOPY OF BIOLOGICAL MOLECULES: MODERN TRENDS, 1997, : 373 - 374
  • [22] A CAMPTOTHECIN-RESISTANT DNA TOPOISOMERASE-I MUTANT EXHIBITS ALTERED SENSITIVITIES TO OTHER DNA TOPOISOMERASE POISONS
    KNAB, AM
    FERTALA, J
    BJORNSTI, MA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) : 6141 - 6148
  • [23] Cytotoxic compounds from Annonaceus species as DNA topoisomerase I poisons
    López-Lázaro, M
    Martín-Cordero, C
    Bermejo, A
    Cortes, D
    Ayuso, MJ
    ANTICANCER RESEARCH, 2001, 21 (05) : 3493 - 3497
  • [24] Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons
    Esselen, Melanie
    Fritz, Jessica
    Hutter, Melanie
    Marko, Doris
    CHEMICAL RESEARCH IN TOXICOLOGY, 2009, 22 (03) : 554 - 564
  • [25] Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
    Hawtin, Rachael E.
    Stockett, David E.
    Byl, Jo Ann W.
    McDowell, Robert S.
    Tan, Nguyen
    Arkin, Michelle R.
    Conroy, Andrew
    Yang, Wenjin
    Osheroff, Neil
    Fox, Judith A.
    PLOS ONE, 2010, 5 (04):
  • [26] FLAVONOIDS AS DNA TOPOISOMERASE ANTAGONISTS AND POISONS - STRUCTURE-ACTIVITY-RELATIONSHIPS
    CONSTANTINOU, A
    MEHTA, R
    RUNYAN, C
    RAO, K
    VAUGHAN, A
    MOON, R
    JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (02): : 217 - 225
  • [27] Recent Developments of DNA Poisons - Human DNA Topoisomerase IIα Inhibitors - as Anticancer Agents
    Pogorelnik, Barbara
    Perdih, Andrej
    Solmajer, Tom
    CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (13) : 2474 - 2488
  • [28] Novel genes affecting cell sensitivity to DNA topoisomerase I poisons
    Reid, RJD
    Fiorani, P
    Bjornsti, MA
    ANNALS OF ONCOLOGY, 1998, 9 : 58 - 58
  • [29] INTERCALATIVE ANTITUMOR DRUGS INTERFERE WITH THE BREAKAGE-REUNION REACTION OF MAMMALIAN DNA TOPOISOMERASE-II
    TEWEY, KM
    CHEN, GL
    NELSON, EM
    LIU, LF
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, 259 (14) : 9182 - 9187
  • [30] Natural Products as Topoisomerase II Poisons: Effects of Thyrnoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα
    Ashley, Rachel E.
    Osheroff, Neil
    CHEMICAL RESEARCH IN TOXICOLOGY, 2014, 27 (05) : 787 - 793
12345