PLATELET FACTOR-IV BLOCKS THE BINDING OF BASIC FIBROBLAST GROWTH-FACTOR TO THE RECEPTOR AND INHIBITS THE SPONTANEOUS MIGRATION OF VASCULAR ENDOTHELIAL-CELLS

被引：75
|
作者：
SATO, Y
ABE, M
TAKAKI, R
机构：
[1] First Department, Medicine Medical College of Oita Idaigaoka, Oita, 879-56, Hazama-cho
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)90715-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Platelet factor 4 (PF-4) blocked the binding of basic fibroblast growth factor (bFGF) to the plasma membrane receptor. Five μg/ml of PF-4 completely blocked the specific binding of bFGF to the receptor of NIH 3T3 cells. Endogenously produced bFGF regulates the spontaneous migration of bovine aortic endothelial (BAE) cells as an autocrine factor (Sato and Rifkin, 1988). PF-4 inhibited the spontaneous migration of BAE cells in a reversible and dose dependent manner. The inhibition reached maximum at 5 μg/ml of PF-4, where the binding of bFGF to the receptor was completely blocked. © 1990.
引用
收藏
页码：595 / 600
页数：6
相关论文
共 50 条
  • [31] COMPARATIVE EFFECTS OF VASCULAR ENDOTHELIAL GROWTH-FACTOR, BASIC FIBROBLAST GROWTH-FACTOR AND NITROPRUSSIDE ON CORONARY MICROVESSELS
    WANG, SY
    SELLKE, FW
    CIRCULATION, 1995, 92 (08) : 3608 - 3608
  • [32] VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) AND BASIC FIBROBLAST GROWTH-FACTOR (BFGF) IN HUMAN PRERETINAL MEMBRANES
    ELIOTT, D
    AMIN, RH
    FRANK, RN
    SAXE, SJ
    PUKLIN, JE
    ABRAMS, GW
    VISION RESEARCH, 1995, 35 : 1443 - 1443
  • [33] ENDOTHELIAL-CELLS CONTAIN A HEPARIN BINDING GROWTH-FACTOR
    GAJDUSEK, C
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 979 - 979
  • [34] SYNERGISTIC EFFECT OF VASCULAR ENDOTHELIAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR ON ANGIOGENESIS IN-VIVO
    ASAHARA, T
    BAUTERS, C
    ZHENG, LP
    TAKESHITA, S
    BUNTING, S
    FERRARA, N
    SYMES, JF
    ISNER, JM
    CIRCULATION, 1995, 92 (09) : 365 - 371
  • [35] PLATELET FACTOR-4-BINDING TO VASCULAR ENDOTHELIAL-CELLS
    RYBAK, ME
    HANDIN, RI
    GIMBRONE, MA
    CIRCULATION, 1980, 62 (04) : 335 - 335
  • [36] MODULATION OF CELL-MIGRATION AND VESSEL FORMATION BY VASCULAR ENDOTHELIAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR IN CULTURED EMBRYONIC HEART
    RATAJSKA, A
    TORRY, RJ
    KITTEN, GT
    KOLKER, SJ
    TOMANEK, RJ
    DEVELOPMENTAL DYNAMICS, 1995, 203 (04) : 399 - 407
  • [37] SENESCENCE OF AORTIC ENDOTHELIAL-CELLS IN CULTURE - EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR EXPRESSION ON CELL PHENOTYPE, MIGRATION, AND PROLIFERATION
    AUGUSTINVOSS, HG
    VOSS, AK
    PAULI, BU
    JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 157 (02) : 279 - 288
  • [38] TRANSFECTION AND EXPRESSION OF SOLUBLE FIBROBLAST GROWTH-FACTOR RECEPTOR IN RAT AORTIC ENDOTHELIAL-CELLS
    LIM, HM
    CARLSON, SG
    CHOI, ME
    BALLERMANN, BJ
    MOLECULAR BIOLOGY OF THE CELL, 1995, 6 : 718 - 718
  • [39] MODULATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR BY BASIC FIBROBLAST GROWTH-FACTOR
    MAHER, PA
    JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 154 (02) : 350 - 358
  • [40] LOCALIZATION OF BASIC FIBROBLAST GROWTH-FACTOR IN BOVINE ENDOTHELIAL-CELLS - IMMUNOHISTOCHEMICAL AND BIOCHEMICAL-STUDIES
    YU, ZX
    BIRO, S
    FU, YM
    SANCHEZ, J
    SMALE, G
    SASSE, J
    FERRANS, VJ
    CASSCELLS, W
    EXPERIMENTAL CELL RESEARCH, 1993, 204 (02) : 247 - 259
12345