ADRENAL-FUNCTION IN ASTHMA

被引：77
|
作者：
PRIFTIS, K
MILNER, AD
CONWAY, E
HONOUR, JW
机构：
[1] UNIV NOTTINGHAM HOSP, QUEENS MED CTR, CHILDRENS RESP UNIT, NOTTINGHAM NG7 2UH, ENGLAND
[2] MIDDLESEX HOSP, LONDON W1, ENGLAND
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 1990年 / 65卷 / 08期
关键词：
D O I：
10.1136/adc.65.8.838
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A dose dependent suppression of daily cortisol excretion was shown in 25 children with asthma being treated with beclomethasone dipropionate. Cortisol metabolites tended to occur below the normal range when doses of beclomethasone of more than 400 μg/m2/day were given. Androgen excretion below the normal range was apparent in asthmatic children aged 8-13 years regardless of whether they were receiving inhaled steroids. This may be the reason for growth delay often seen in asthmatic children. These side effects of beclomethasone are not enough reason to discourage its prescription for the treatment of asthma, but endocrine aassessment is desirable when the dose exceeds 400 μg/m2/day.
引用
收藏
页码：838 / 840
页数：3
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