ADRENAL-FUNCTION IN ASTHMA

被引：77
|
作者：
PRIFTIS, K
MILNER, AD
CONWAY, E
HONOUR, JW
机构：
[1] UNIV NOTTINGHAM HOSP, QUEENS MED CTR, CHILDRENS RESP UNIT, NOTTINGHAM NG7 2UH, ENGLAND
[2] MIDDLESEX HOSP, LONDON W1, ENGLAND
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 1990年 / 65卷 / 08期
关键词：
D O I：
10.1136/adc.65.8.838
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A dose dependent suppression of daily cortisol excretion was shown in 25 children with asthma being treated with beclomethasone dipropionate. Cortisol metabolites tended to occur below the normal range when doses of beclomethasone of more than 400 μg/m2/day were given. Androgen excretion below the normal range was apparent in asthmatic children aged 8-13 years regardless of whether they were receiving inhaled steroids. This may be the reason for growth delay often seen in asthmatic children. These side effects of beclomethasone are not enough reason to discourage its prescription for the treatment of asthma, but endocrine aassessment is desirable when the dose exceeds 400 μg/m2/day.
引用
收藏
页码：838 / 840
页数：3
相关论文
共 50 条
  • [1] ADRENAL-FUNCTION IN ACUTE SEVERE ASTHMA
    KARALUS, NC
    DUNN, PJ
    MAHOOD, CB
    SPEED, JF
    [J]. NEW ZEALAND MEDICAL JOURNAL, 1986, 99 (797) : 164 - 164
  • [2] ADRENAL-FUNCTION IN ACUTE SEVERE ASTHMA
    KARALUS, NC
    MAHOOD, CB
    DUNN, PJ
    SPEED, JF
    [J]. NEW ZEALAND MEDICAL JOURNAL, 1985, 98 (788) : 843 - 846
  • [3] SEPSIS AND ADRENAL-FUNCTION
    SIEGEL, LM
    GRINSPOON, SK
    GARVEY, GJ
    BILEZIKIAN, JP
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1994, 5 (08): : 324 - 328
  • [4] EVALUATING ADRENAL-FUNCTION
    HAGEN, TC
    [J]. CONTEMPORARY OB GYN, 1980, 16 (06) : 35 - &
  • [5] STRESS AND ADRENAL-FUNCTION
    HARVEY, S
    PHILLIPS, JG
    REES, A
    HALL, TR
    [J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1984, 232 (03): : 633 - 645
  • [6] ADRENAL-FUNCTION IN TUBERCULOSIS
    ELLIS, ME
    TAYOUB, F
    [J]. BRITISH JOURNAL OF DISEASES OF THE CHEST, 1986, 80 (01): : 7 - 17
  • [7] ADRENAL-FUNCTION OF CHILDREN WITH BRONCHIAL-ASTHMA TREATED WITH BECLOMETHASONE DIPROPIONATE
    KATSUNUMA, T
    AKASAWA, A
    IIKURA, Y
    [J]. ANNALS OF ALLERGY, 1992, 69 (06): : 529 - 532
  • [8] EFFECT OF BEDREST ON ADRENAL-FUNCTION
    LEACH, CS
    HULLEY, SB
    RAMBAUT, PC
    DIETLEIN, LF
    [J]. SPACE LIFE SCIENCES, 1973, 4 (3-4): : 415 - 423
  • [9] EFFECT OF ETOMIDATE ON ADRENAL-FUNCTION
    WATT, I
    FRASER, R
    KENYON, C
    LEVER, AF
    BEASTALL, G
    LEDINGHAM, JM
    [J]. BRITISH JOURNAL OF SURGERY, 1984, 71 (05) : 380 - 380
  • [10] ACTIVATION OF FETAL ADRENAL-FUNCTION
    CHALLIS, JRG
    MITCHELL, BF
    LYE, SJ
    [J]. JOURNAL OF DEVELOPMENTAL PHYSIOLOGY, 1984, 6 (01) : 93 - 105
12345