SYNTHESIS OF 1-(BENZOTRIAZOL-1-YL)ALKYLDIPHENYLPHOSPHINE OXIDES AND THEIR TRANSFORMATIONS TO NOVEL BENZOTRIAZOL-1-YL-SUBSTITUTED CYCLOPROPANES

Diphenylphosphinous anion reacted with chloromethylbenzotriazole to give (benzotriazol-1-yl)methyldiphenylphosphine oxide, which, after lithiation, was alkylated to give 1-(benzotriazol-1-yl)alkyldiphenylphosphine oxides in good yield. Treatment of 1-(benzotriazal-1-yl)alkyldiphenylphosphine oxides with n-butyllithium followed by condensation with epoxides, afforded benzotriazol-1-yl-substituted cyclopropanes, which unverwent further lithiation and subsequent reaction with numerous electrophiles to provide variety of novel benzotriazol-1-yl-substituted cyclopropane derivatives.