SYNTHESIS OF 1-(BENZOTRIAZOL-1-YL)ALKYLDIPHENYLPHOSPHINE OXIDES AND THEIR TRANSFORMATIONS TO NOVEL BENZOTRIAZOL-1-YL-SUBSTITUTED CYCLOPROPANES

被引：6
|
作者：
KATRITZKY, AR
WU, H
XIE, LH
JIANG, JL
机构：
[1] Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 02期
关键词：
D O I：
10.1002/jhet.5570320238
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Diphenylphosphinous anion reacted with chloromethylbenzotriazole to give (benzotriazol-1-yl)methyldiphenylphosphine oxide, which, after lithiation, was alkylated to give 1-(benzotriazol-1-yl)alkyldiphenylphosphine oxides in good yield. Treatment of 1-(benzotriazal-1-yl)alkyldiphenylphosphine oxides with n-butyllithium followed by condensation with epoxides, afforded benzotriazol-1-yl-substituted cyclopropanes, which unverwent further lithiation and subsequent reaction with numerous electrophiles to provide variety of novel benzotriazol-1-yl-substituted cyclopropane derivatives.
引用
收藏
页码：595 / 598
页数：4
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