GLUCOSYLATION OF THIOCOLCHICINE BY A CELL-SUSPENSION CULTURE OF CENTELLA-ASIATICA

被引：18

作者：

SOLET, JM

BISTERMIEL, F

GALONS, H

SPAGNOLI, R

GUIGNARD, JL

COSSON, L

机构：

[1] ROUSSEL UCLAF,DEPT BIOTECHNOL,F-93230 ROMAINVILLE,FRANCE

[2] FAC PHARM PARIS,INTERNAL MED LAB,F-75270 PARIS 06,FRANCE

来源：

PHYTOCHEMISTRY | 1993年 / 33卷 / 04期

关键词：

CENTELLA-ASIATICA; APIACEAE; GLUCOSYLATION; BIOTRANSFORMATION; PLANT CELL CULTURE; THIOCOLCHICINE; THIOCOLCHICOSIDE;

D O I：

10.1016/0031-9422(93)85281-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thiocolchicine, a hemisynthetic substrate obtained from natural colchicine, was converted to its 2-O- and 3-O-monoglucosyl derivatives by cell suspension cultures of Centella asiatica. In view of its cytotoxic effects, the thiocolchicine was administered to seven-day-old suspension cultures. The amounts and the compartmentation of products were then measured over a 12-day period. The results showed the intracellular localization of glucosides.

引用

页码：817 / 820

页数：4

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