INDUCTION OF RESISTANCE OF STREPTOCOCCUS-PNEUMONIAE TO QUINOLONES INVITRO

被引：18
|
作者：
LAFREDO, SC [1 ]
FOLENO, BD [1 ]
FU, KP [1 ]
机构：
[1] RW JOHNSON PHARMACEUT,RES INST,RARITAN,NJ 08869
来源：
CHEMOTHERAPY | 1993年 / 39卷 / 01期
关键词：
QUINOLONES; LEVOFLOXACIN; CIPROFLOXACIN; TEMAFLOXACIN; NORFLOXACIN; RESISTANCE INDUCTION; STREPTOCOCCUS-PNEUMONIAE;
D O I：
10.1159/000238971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Twelve strains of Streptococcus pneumoniae were serially exposed to increasing concentrations of levofloxacin, temafloxacin, ciprofloxacin and norfloxacin for five passages. Wild-type and passaged strains were tested for susceptibility to quinolones, macrolide and penicillin G. The MIC90 data showed a 2-fold increase for levofloxacin but a 32-fold increase for ciprofloxacin, a 16-fold increase for temafloxacin and an 8-fold increase for norfloxacin. Among 16 ciprofloxacin-induced resistant strains, 14 were susceptible to levofloxacin. No cross-resistance to other antibiotics was observed.
引用
收藏
页码：36 / 39
页数：4
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