THE SUPPRESSION OF OLFACTORY BULBECTOMY-INDUCED MURICIDE BY ANTIDEPRESSANTS AND ANTIHISTAMINES VIA HISTAMINE H1 RECEPTOR BLOCKING

被引：22
|
作者：
NOGUCHI, S [1 ]
INUKAI, T [1 ]
KUNO, T [1 ]
TANAKA, C [1 ]
机构：
[1] KOBE UNIV,SCH MED,DEPT PHARMACOL,KOBE 650,JAPAN
来源：
PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期
关键词：
MURICIDE; OLFACTORY BULBECTOMY; ANTIDEPRESSANTS; ANTIHISTAMINES; HISTAMINE H1 RECEPTOR;
D O I：
10.1016/0031-9384(92)90297-F
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier, suppressed muricide. The drugs which have high affinity for histamine H1 receptor showed potent suppressive effect on muricide. It is suggested that the central histaminergic system is involved via H1 receptors in the expression of muricide in olfactory bulbectomized rats.
引用
收藏
页码：1123 / 1127
页数：5
相关论文
共 50 条
  • [41] Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice
    Izumizaki, M
    Iwase, M
    Kimura, H
    Yanai, K
    Watanabe, T
    Watanabe, T
    Homma, I
    NEUROSCIENCE LETTERS, 2000, 284 (03) : 139 - 142
  • [42] Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin
    Tashiro, Manabu
    Duan, Xudong
    Kato, Motohisa
    Miyake, Masayasu
    Watanuki, Shoichi
    Ishikawa, Yoichi
    Funaki, Yoshihito
    Iwata, Ren
    Itoh, Masatoshi
    Yanai, Kazuhiko
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (06) : 811 - 821
  • [43] β2-Adrenergic receptor activation-induced histamine H1 receptor down-regulation
    Fukui, H
    Kawakami, N
    Miyoshi, K
    Kodama, M
    Horio, S
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 250P - 250P
  • [44] PRESEASONAL PROPHYLACTIC TREATMENT WITH ANTIHISTAMINES SUPPRESSES NASAL SYMPTOMS AND EXPRESSION OF HISTAMINE H1 RECEPTOR mRNA IN THE NASAL MUCOSA OF PATIENTS WITH POLLINOSIS
    Mizuguchi, H.
    Kitamura, Y.
    Kondo, Y.
    Kuroda, W.
    Yoshida, H.
    Miyamoto, Y.
    Hattori, M.
    Fukui, H.
    Takeda, N.
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2010, 32 (10): : 745 - 748
  • [45] Mechanically induced active conformation of the histamine H1 receptor differs from agonist induced active conformation
    Erdogmus, S.
    Storch, U.
    Winter, M.
    Gudermann, T.
    Schnitzler y Mederos, M.
    ACTA PHYSIOLOGICA, 2014, 210 : 80 - 80
  • [46] Histamine generates calcium transients via H1 receptor in a human cytotrophoblast cell line.
    Liu, ZT
    Paria, BC
    Armant, DR
    BIOLOGY OF REPRODUCTION, 2001, 64 : 205 - 205
  • [47] Histamine H3 receptor antagonist-induced pruritus can be inhibited by blockade of histamine H1 and H4 receptors
    Rossbach, K.
    Stark, H.
    Sander, K.
    Kietzmann, M.
    Baeumer, W.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2009, 32 : 220 - 220
  • [48] EVALUATION OF RESIDUAL SEDATIVE EFFECT OF ANTIHISTAMINES BY MEASURING CENTRAL HISTAMINE H1 RECEPTOR OCCUPANCY USING 11C-DOXEPIN-PET
    Yanai, Kazuhiko
    Zhang, Dongying
    Manabu, Tashiro
    Shibuya, Katsuhiko
    ACTA DERMATO-VENEREOLOGICA, 2009, 89 (06) : 707 - 707
  • [49] Involvement of βγ subunits of G protein in cAMP response induced by stimulation of histamine H1 receptor.
    Maruko, T
    Nakahara, T
    Sakamoto, K
    Ishii, K
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 91 : 238P - 238P
  • [50] Effects of vasopressin on histamine H1 receptor antagonist-induced spatial memory deficits in rats
    Taga, C
    Sugimoto, Y
    Nishiga, M
    Fujii, Y
    Kamei, C
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 423 (2-3) : 167 - 170
12345