THE SUPPRESSION OF OLFACTORY BULBECTOMY-INDUCED MURICIDE BY ANTIDEPRESSANTS AND ANTIHISTAMINES VIA HISTAMINE H1 RECEPTOR BLOCKING

被引：22
|
作者：
NOGUCHI, S [1 ]
INUKAI, T [1 ]
KUNO, T [1 ]
TANAKA, C [1 ]
机构：
[1] KOBE UNIV,SCH MED,DEPT PHARMACOL,KOBE 650,JAPAN
来源：
PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期
关键词：
MURICIDE; OLFACTORY BULBECTOMY; ANTIDEPRESSANTS; ANTIHISTAMINES; HISTAMINE H1 RECEPTOR;
D O I：
10.1016/0031-9384(92)90297-F
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier, suppressed muricide. The drugs which have high affinity for histamine H1 receptor showed potent suppressive effect on muricide. It is suggested that the central histaminergic system is involved via H1 receptors in the expression of muricide in olfactory bulbectomized rats.
引用
收藏
页码：1123 / 1127
页数：5
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