OXIDATIVE POLYMORPHISM OF DEBRISOQUINE IS NOT RELATED TO HUMAN COLORECTAL-CANCER

被引：4
|
作者：
LADERO, JM
BENITEZ, J
GONZALEZ, JF
VARGAS, E
DIAZRUBIO, M
机构：
[1] UNIV COMPLUTENSE MADRID,DEPT MED,MADRID 3,SPAIN
[2] UNIV EXTREMADURA,DEPT PHARMACOL,BADAJOZ,SPAIN
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 40卷 / 05期
关键词：
COLON CANCER; POLYMORPHISM; DEBRISOQUINE; RECTAL CANCER; CYTOCHROME-P-450;
D O I：
10.1007/BF00315234
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The oxidative polymorphism of debrisoquine (DBQ) has been determined in 89 patients with colo-rectal cancer and in 556 normal control subjects. Four patients and 34 controls, with a metabolic ratio > 12.6, were classified as poor metabolisers of DBQ (n.s.). No difference was found in the distribution of the frequencies of the MR of DBQ between patients and controls. It is concluded that polymorphic oxidation of DBQ is not related to the risk of developing colo-rectal cancer in human beings.
引用
收藏
页码：525 / 527
页数：3
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