REPEATED D-1 RECEPTOR AGONIST TREATMENT BLOCKS COCAINE-INDUCED LOCOMOTOR-ACTIVITY AND C-FOS EXPRESSION

被引：17

作者：

ASIN, KE ^{[1
]}

NIKKEL, AL ^{[1
]}

WIRTSHAFTER, D ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT PSYCHOL,CHICAGO,IL 60680

来源：

BRAIN RESEARCH | 1994年 / 637卷 / 1-2期

关键词：

COCAINE; DOPAMINE D-1 RECEPTOR; C-FOS GENE EXPRESSION; SUBSENSITIVITY; A-77636;

D O I：

10.1016/0006-8993(94)91258-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pretreatment of rats for 4 days with the selective dopamine D, receptor agonist A-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D-1 agonist treatment leads to subsensitivity of D-1 receptors involved in mediating some of the effects of cocaine on behavior and gene expression.

引用

页码：342 / 344

页数：3

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