AN HPLC PROCEDURE FOR THE ENANTIOMERIC PURITY OF AN OPTICALLY-ACTIVE CYTOSINE ANALOG USING LIGAND-EXCHANGE

被引：15

作者：

PACK, EJ ^{[1
]}

BLEIBERG, B ^{[1
]}

ROSENBERG, IE ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,5 RES PKWY,DEPT 902,WALLINGFORD,CT 06492

来源：

CHIRALITY | 1990年 / 2卷 / 04期

关键词：

antiviral; chiral separation; complexation; ion‐pairing; nucleotide analogue;

D O I：

10.1002/chir.530020414

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An acylonucleotide analogue, 1‐[3‐hydroxy‐2‐(phosphonyl‐methoxy)propyl]cytosine (HPMPC), has shown activity against herpes simplex Type I and Type II viruses. An HPLC separation of the R‐ and S‐enantiomers of HPMPC by ligand exchange using a mobile phase containing phenylalanine as the chiral modifier and copper(II) as the metal ion is reported. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：275 / 279

页数：5