AN HPLC PROCEDURE FOR THE ENANTIOMERIC PURITY OF AN OPTICALLY-ACTIVE CYTOSINE ANALOG USING LIGAND-EXCHANGE

被引：15

作者：

PACK, EJ ^{[1
]}

BLEIBERG, B ^{[1
]}

ROSENBERG, IE ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,5 RES PKWY,DEPT 902,WALLINGFORD,CT 06492

来源：

CHIRALITY | 1990年 / 2卷 / 04期

关键词：

antiviral; chiral separation; complexation; ion‐pairing; nucleotide analogue;

D O I：

10.1002/chir.530020414

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An acylonucleotide analogue, 1‐[3‐hydroxy‐2‐(phosphonyl‐methoxy)propyl]cytosine (HPMPC), has shown activity against herpes simplex Type I and Type II viruses. An HPLC separation of the R‐ and S‐enantiomers of HPMPC by ligand exchange using a mobile phase containing phenylalanine as the chiral modifier and copper(II) as the metal ion is reported. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：275 / 279

页数：5

共 42 条

[1] SORBENTS WITH GROUPS OF OPTICALLY-ACTIVE ALPHA-AMINOETHYLPHOSPHONIC ACIDS FOR LIGAND-EXCHANGE CHROMATOGRAPHY OF RACEMATES
BELOV, YP
DAVANKOV, VA
ROGOZHIN, SV
BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, 1977, 26 (08): : 1718 - 1722
[2] OPTICALLY-ACTIVE TRANSITION-METAL COMPLEXES .44. NATURE OF CHIRAL INTERMEDIATES INVOLVED IN RACEMIZATION AND LIGAND-EXCHANGE REACTIONS OF OPTICALLY-ACTIVE MANGANESE COMPOUNDS
BRUNNER, H
STEGER, W
BULLETIN DES SOCIETES CHIMIQUES BELGES, 1976, 85 (11): : 883 - 891
[3] DETERMINATION OF OPTICAL PURITY OF (S)-(-)-OFLOXACIN BY HPLC USING AN OPTICALLY-ACTIVE MOBILE PHASE
ARAI, T
KURODA, H
BUNSEKI KAGAKU, 1989, 38 (11) : 650 - 652
[4] SIMPLE SYNTHESIS OF OPTICALLY-ACTIVE 2-FLUOROPROPANOIC ACID AND ANALOGS OF HIGH ENANTIOMERIC PURITY
FRITZLANGHALS, E
SCHUTZ, G
TETRAHEDRON LETTERS, 1993, 34 (02) : 293 - 296
[5] APPLICATION OF OPTICALLY-ACTIVE PHOSPHINOTHIOIC ACID AS CHIRAL SHIFT-REAGENT TO DETERMINATION OF ENANTIOMERIC PURITY
MORIYAMA, M
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1984, 42 (04) : 355 - 361
[6] OPTICALLY-ACTIVE, AROMATIC SPIRANES .8. SYNTHESES OF OPTICALLY-ACTIVE, 5,5',6'-TRISUBSTITUTED 2,2'-SPIROBIINDANES OF KNOWN CHIRALITY AND ENANTIOMERIC PURITY
NEUDECK, H
SCHLOGL, K
MONATSHEFTE FUR CHEMIE, 1979, 110 (03): : 541 - 565
[7] Direct enantiomeric purity determination of acetyl-L-carnitine by LC with a ligand-exchange chiral stationary phase
Kagawa, M
Machida, Y
Nishi, H
Haginaka, J
CHROMATOGRAPHIA, 2005, 62 (5-6) : 239 - 244
[8] Direct Enantiomeric Purity Determination of Acetyl-L-carnitine by LC with a Ligand-Exchange Chiral Stationary Phase
M. Kagawa
Y. Machida
H. Nishi
J. Haginaka
Chromatographia, 2005, 62 : 239 - 244
[9] SYNTHESIS AND ENANTIOMERIC PURITY DETERMINATION OF THE OPTICALLY-ACTIVE EPOXIDE DISPARLURE, SEX-PHEROMONE OF THE GYPSY-MOTH
PIRKLE, WH
RINALDI, PL
JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (07): : 1025 - 1028
[10] OPTICALLY-ACTIVE SPIRANES .11. SYNTHESES OF OPTICALLY-ACTIVE MONO TO HEPTASUBSTITUTED 5-METHYL AND ETHYL-2,2'-SPIROBIINDANES AND RELATED NAPHTHALENE DERIVATIVES OF KNOWN CHIRALITY AND ENANTIOMERIC PURITY
NEUDECK, H
SCHLOGL, K
MONATSHEFTE FUR CHEMIE, 1981, 112 (6-7): : 801 - 823

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