High and steady yields are a major objective for any agricultural holding and, in the case of fruit tree plantations, the specific market requirements are an additional goal. The implementation of a sustainable agriculture system requires a smaller amount of pesticides, less environmental pollution, more efficient technologies, biodiversity and resource conservation by means of input reduction, output and holding lucrativity increase and resource redistribution. The paper aims to find the best fertilization and weed control solution in a plum tree plantation in the pedoclimatic conditions of Moara Domneasca. The findings were that the obtained yields varied greatly according to the fertilizer and herbicide treatments. Thus, the application of a total herbicide in fractionated doses resulted in more efficient weed control compared to a single dose application. Regarding fertilization, the best results were obtained in the treatments with both soil and leaf applications. Concerning yield levels, they varied between 6.9 t/ha in the treatment with no herbicidation and no fertilization and a maximum level of 14.6 t/ha, where weed control was performed by applying two doses of herbicide and combined soil and leaf fertilization.