INTERACTION OF EUROPIUM CHELATES WITH LIPID MONOLAYERS

被引：0

作者：

Trusova, V. ^{[1
]}

Yudintsev, A. ^{[1
]}

Kutsenko, O. ^{[1
]}

Pakhomova, O. ^{[1
]}

Volinsky, R. ^{[2
]}

Gorbenko, G. ^{[1
]}

Deligeorgiev, T. ^{[3
]}

Kinnunen, P. ^{[2
]}

机构：

[1] Kharkov Natl Univ, Dept Biol & Med Phys, 4 Svobody Sq, UA-61022 Kharkov, Ukraine

[2] Aalto Univ, Sch Sci & Technol, Dept Biomed Engn & Computat Sci, FI-00076 Espoo, Finland

[3] Univ Sofia, Fac Chem & Pharm, Dept Appl Organ Chem, Sofia 1164, Bulgaria

来源：

EAST EUROPEAN JOURNAL OF PHYSICS | 2014年 / 1卷 / 04期

关键词：

europium complexes; anticancer drugs; Langmuir monolayers; membrane penetration;

D O I：

暂无

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The ability of novel anticancer drug candidates, europium coordination complexes (EC), to penetrate the phospholipid monolayer composed of dimyristoylphosphatidylcholine (DMPC) was studied using Langmuir monolayer technique. EC were found to insert readily into the lipid monolayer with penetration extent being dependent on both drug structure and initial surface pressure of the lipid film. Evaluation of the limiting surface pressure revealed that all drugs are capable of inserting into the cellular membranes.

引用

页码：100 / 105

页数：6

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