SPLICING OF AN ANTISENSE ALU SEQUENCE GENERATES A CODING SEQUENCE VARIANT FOR THE ALPHA-3 SUBUNIT OF A NEURONAL ACETYLCHOLINE-RECEPTOR

被引：11

作者：

MIHOVILOVIC, M ^{[1
]}

MAI, Y ^{[1
]}

HERBSTREITH, M ^{[1
]}

RUBBOLI, F ^{[1
]}

TARRONI, P ^{[1
]}

CLEMENTI, F ^{[1
]}

ROSES, AD ^{[1
]}

机构：

[1] UNIV MILAN,DEPT FARMACOL CHEMOTERAPIA & TOSSICOL MED,I-20129 MILAN,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this report we demonstrate that an α-3 acetylcholine receptor subunit transcriptional variant originates through alternative splicing of a complementary sequence of the right arm of an Alu element. This element is located within the 5.1Kb intron found between axons 5 and 6 of the α-3 acetylcholine receptor subunit gene. The transcriptional variant originates from the normal splicing process and carries an in-frame stop codon. If translated, it should encode for a peptide lacking the 4th transmembrane domain of the normal subunit. © 1993 Academic Press, Inc.

引用

页码：137 / 144

页数：8

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