SPLICING OF AN ANTISENSE ALU SEQUENCE GENERATES A CODING SEQUENCE VARIANT FOR THE ALPHA-3 SUBUNIT OF A NEURONAL ACETYLCHOLINE-RECEPTOR

被引：11
|
作者：
MIHOVILOVIC, M [1 ]
MAI, Y [1 ]
HERBSTREITH, M [1 ]
RUBBOLI, F [1 ]
TARRONI, P [1 ]
CLEMENTI, F [1 ]
ROSES, AD [1 ]
机构：
[1] UNIV MILAN,DEPT FARMACOL CHEMOTERAPIA & TOSSICOL MED,I-20129 MILAN,ITALY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 01期
关键词：
D O I：
10.1006/bbrc.1993.2452
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this report we demonstrate that an α-3 acetylcholine receptor subunit transcriptional variant originates through alternative splicing of a complementary sequence of the right arm of an Alu element. This element is located within the 5.1Kb intron found between axons 5 and 6 of the α-3 acetylcholine receptor subunit gene. The transcriptional variant originates from the normal splicing process and carries an in-frame stop codon. If translated, it should encode for a peptide lacking the 4th transmembrane domain of the normal subunit. © 1993 Academic Press, Inc.
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页码：137 / 144
页数：8
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