Effect cardiac, inflamatory and endothelial of transplanted patients, with renal chronic disease. Series cases

Introduction: Hypertension (HTA) is an important factor in the development of cardiovascular disease in patients with chronic kidney disease stage V (ERC Stadium V). OBJECTIVE: Assess inflammatory and cardiovascular endothelial changes in hypertensive patients with ERC Stadium V post transplanted. METHODS: Prospective study with 7 hypertensive patients with ERC Stadium V post transplanted kidney, treated with: Beta blockers, inhibitor of ACE angiotensin (ACEI) or angiotensin AT1 receptor antagonist. Assessed: clinic, echocardiographic parameters, paraclinicos; inflammatory and endothelial markers: Protein C reactive Ultrasensible (usCRP), Peptide natriuretic (NTproBNP) method PATHFATH; Factor of Necrosis Tumor Alpha (TNF alpha) Elisa method and HomocysteineDiasys diagnostic systems international, before and six months of kidney transplantation. Statistical analysis: Student's t was used for matched data (p < 0,05). RESULTS: Statistical significant improvement was observed to level echocardiography: diameters of cavities and the left ventricle ejection fraction. Inflammatory markers: NTproBNP, TNF, alpha Homocysteine and decline of theusCRP. CONCLUSIONS: Control of 7 hypertensive patients in status post kidney transplant, showed improvement: clinic, metabolic, morphological cardiac, and endothelial and inflammatory markers. Suggesting creating multidisciplinary teams that include cardiologists and used with beta-blockers and ACEI therapy AT1 antihypertensive therapies, for proper control of these patients and reducing the incidence of kidney rejection and cardiovascular death.